Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content
Quantitative nuclear magnetic resonance (qNMR) is a powerful tool in measuring drug content because of its high speed, sensitivity, and precision. Most of the reports were based on proton qNMR (1H qNMR) and only a few fluorine qNMR (19F qNMR) were reported. No research has been conducted to directly...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/7627823 |
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| author | Yang Liu Zhaoxia Liu Huaxin Yang Lan He |
| author_facet | Yang Liu Zhaoxia Liu Huaxin Yang Lan He |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Quantitative nuclear magnetic resonance (qNMR) is a powerful tool in measuring drug content because of its high speed, sensitivity, and precision. Most of the reports were based on proton qNMR (1H qNMR) and only a few fluorine qNMR (19F qNMR) were reported. No research has been conducted to directly compare the advantage and disadvantage between these two methods. In the present study, both 19F and 1H qNMR were performed to characterize the content of atorvastatin calcium with the same internal standard. Linearity, precision, and results from two methods were compared. Results showed that 19F qNMR has similar precision and sensitivity to 1H qNMR. Both methods generate similar results compared to mass balance method. Major advantage from 19F qNMR is that the analyte signal is with less or no interference from impurities. 19F qNMR is an excellent approach to quantify fluorine-containing analytes. |
| format | Article |
| id | doaj-art-03799b09acf84b32b6341dd4374d983d |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-03799b09acf84b32b6341dd4374d983d2025-02-03T06:00:21ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/76278237627823Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium ContentYang Liu0Zhaoxia Liu1Huaxin Yang2Lan He3National Institutes for Food and Drug Control, Beijing 100050, ChinaNational Institutes for Food and Drug Control, Beijing 100050, ChinaNational Institutes for Food and Drug Control, Beijing 100050, ChinaNational Institutes for Food and Drug Control, Beijing 100050, ChinaQuantitative nuclear magnetic resonance (qNMR) is a powerful tool in measuring drug content because of its high speed, sensitivity, and precision. Most of the reports were based on proton qNMR (1H qNMR) and only a few fluorine qNMR (19F qNMR) were reported. No research has been conducted to directly compare the advantage and disadvantage between these two methods. In the present study, both 19F and 1H qNMR were performed to characterize the content of atorvastatin calcium with the same internal standard. Linearity, precision, and results from two methods were compared. Results showed that 19F qNMR has similar precision and sensitivity to 1H qNMR. Both methods generate similar results compared to mass balance method. Major advantage from 19F qNMR is that the analyte signal is with less or no interference from impurities. 19F qNMR is an excellent approach to quantify fluorine-containing analytes.http://dx.doi.org/10.1155/2016/7627823 |
| spellingShingle | Yang Liu Zhaoxia Liu Huaxin Yang Lan He Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content Journal of Analytical Methods in Chemistry |
| title | Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content |
| title_full | Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content |
| title_fullStr | Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content |
| title_full_unstemmed | Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content |
| title_short | Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content |
| title_sort | direct comparison of 19f qnmr and 1h qnmr by characterizing atorvastatin calcium content |
| url | http://dx.doi.org/10.1155/2016/7627823 |
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