Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data
Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection. A long-acting delivery system could provide several advantages as a formulation strat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340924011442 |
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| author | Sungmin Jung Jack Bufton Zeqing Bao Wonjoon Cho Dean Aguiar Christine Allen |
| author_facet | Sungmin Jung Jack Bufton Zeqing Bao Wonjoon Cho Dean Aguiar Christine Allen |
| author_sort | Sungmin Jung |
| collection | DOAJ |
| description | Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection. A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide-co-glycolide) [1]. To expand the range of polymers available for use, cross-linkable allyl functionalized, polyester copolymers were considered for preparation of disc-shaped, implantable delivery systems for TAF. The physico-chemical properties of the implants were evaluated including thermal and spectral properties as well as in vitro stability. Subsequently the discs were loaded with TAF via a swelling-equilibrium approach and the discs were further characterized including, TAF loading and in vitro drug release. This dataset shows the potential of using these polymeric materials as a sustained delivery platform for TAF. The dataset is freely available on Mendeley Data. |
| format | Article |
| id | doaj-art-03718f9b6f554574b5276df8508de8c6 |
| institution | Kabale University |
| issn | 2352-3409 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj-art-03718f9b6f554574b5276df8508de8c62025-01-31T05:11:26ZengElsevierData in Brief2352-34092025-02-0158111182Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley DataSungmin Jung0Jack Bufton1Zeqing Bao2Wonjoon Cho3Dean Aguiar4Christine Allen5Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, CanadaLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, CanadaLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, CanadaLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, CanadaPendant Inc, JLabs Toronto, 661 University Avenue, Suite 1300, Toronto M5G 0B7, CanadaLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada; Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada; Corresponding author at: Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection. A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide-co-glycolide) [1]. To expand the range of polymers available for use, cross-linkable allyl functionalized, polyester copolymers were considered for preparation of disc-shaped, implantable delivery systems for TAF. The physico-chemical properties of the implants were evaluated including thermal and spectral properties as well as in vitro stability. Subsequently the discs were loaded with TAF via a swelling-equilibrium approach and the discs were further characterized including, TAF loading and in vitro drug release. This dataset shows the potential of using these polymeric materials as a sustained delivery platform for TAF. The dataset is freely available on Mendeley Data.http://www.sciencedirect.com/science/article/pii/S2352340924011442PharmaceuticsLong-acting therapeuticsPolymersTenofovir alafenamideSustained release |
| spellingShingle | Sungmin Jung Jack Bufton Zeqing Bao Wonjoon Cho Dean Aguiar Christine Allen Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data Data in Brief Pharmaceutics Long-acting therapeutics Polymers Tenofovir alafenamide Sustained release |
| title | Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data |
| title_full | Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data |
| title_fullStr | Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data |
| title_full_unstemmed | Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data |
| title_short | Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data |
| title_sort | data characterizing a panel of biodegradable cross linked polyester implants for sustained delivery of an anti viral drugmendeley data |
| topic | Pharmaceutics Long-acting therapeutics Polymers Tenofovir alafenamide Sustained release |
| url | http://www.sciencedirect.com/science/article/pii/S2352340924011442 |
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