Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis
Abstract Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical interventions, are often associated with significa...
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| Format: | Article |
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Wiley
2024-11-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409778 |
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| author | Huaichao Liu Xiaohui Dai Na Li Le Zhang Zihan Wang Ke Ren Yulei Li Xiao Sun Jipeng Wan |
| author_facet | Huaichao Liu Xiaohui Dai Na Li Le Zhang Zihan Wang Ke Ren Yulei Li Xiao Sun Jipeng Wan |
| author_sort | Huaichao Liu |
| collection | DOAJ |
| description | Abstract Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical interventions, are often associated with significant side effects and high recurrence rates. Consequently, there is an urgent need for innovative and safer therapeutic approaches. In this study, an injectable magnetic hydrogel nanosystem is developed designed for the dual‐purpose magnetothermal and anti‐inflammatory treatment of endometriosis. This hydrogel incorporates Fe3O4 nanoparticles alongside an anti‐inflammatory peptide. Upon magnetic activation, the Fe3O4 nanoparticles induce a localized hyperthermic response, raising the temperature of endometriotic lesions to 63.3 °C, effectively destroying endometriotic cells. Concurrently, the thermally responsive hydrogel facilitates the controlled release of the anti‐inflammatory peptide, thus modulating the inflammatory milieu. The biocompatibility and complete in vivo degradability of the hydrogel further enhance its therapeutic potential. The in vivo studies demonstrated that this injectable magnetic hydrogel system achieved a 90% reduction in the volume of endometriotic lesions and significantly decreased inflammatory markers, offering a promising non‐invasive treatment modality for endometriosis. By integrating precise lesion ablation with the modulation of the inflammatory microenvironment, this system represents a novel approach to the clinical management of endometriosis. |
| format | Article |
| id | doaj-art-036a9c8dcc924bfbafb6df2fd6dafef6 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-036a9c8dcc924bfbafb6df2fd6dafef62025-08-20T01:52:38ZengWileyAdvanced Science2198-38442024-11-011144n/an/a10.1002/advs.202409778Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of EndometriosisHuaichao Liu0Xiaohui Dai1Na Li2Le Zhang3Zihan Wang4Ke Ren5Yulei Li6Xiao Sun7Jipeng Wan8Department of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaSchool of Chemistry and Pharmaceutical Engineering Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan 250000 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaSchool of Chemistry and Pharmaceutical Engineering Medical Science and Technology Innovation Center Shandong First Medical University and Shandong Academy of Medical Sciences Jinan 250000 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaDepartment of Gynecology Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 ChinaAbstract Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical interventions, are often associated with significant side effects and high recurrence rates. Consequently, there is an urgent need for innovative and safer therapeutic approaches. In this study, an injectable magnetic hydrogel nanosystem is developed designed for the dual‐purpose magnetothermal and anti‐inflammatory treatment of endometriosis. This hydrogel incorporates Fe3O4 nanoparticles alongside an anti‐inflammatory peptide. Upon magnetic activation, the Fe3O4 nanoparticles induce a localized hyperthermic response, raising the temperature of endometriotic lesions to 63.3 °C, effectively destroying endometriotic cells. Concurrently, the thermally responsive hydrogel facilitates the controlled release of the anti‐inflammatory peptide, thus modulating the inflammatory milieu. The biocompatibility and complete in vivo degradability of the hydrogel further enhance its therapeutic potential. The in vivo studies demonstrated that this injectable magnetic hydrogel system achieved a 90% reduction in the volume of endometriotic lesions and significantly decreased inflammatory markers, offering a promising non‐invasive treatment modality for endometriosis. By integrating precise lesion ablation with the modulation of the inflammatory microenvironment, this system represents a novel approach to the clinical management of endometriosis.https://doi.org/10.1002/advs.202409778anti‐inflammatory therapydrug releaseendometriosisinjectable hydrogelmagnetothermal treatment |
| spellingShingle | Huaichao Liu Xiaohui Dai Na Li Le Zhang Zihan Wang Ke Ren Yulei Li Xiao Sun Jipeng Wan Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis Advanced Science anti‐inflammatory therapy drug release endometriosis injectable hydrogel magnetothermal treatment |
| title | Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis |
| title_full | Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis |
| title_fullStr | Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis |
| title_full_unstemmed | Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis |
| title_short | Injectable Magnetic Hydrogel Incorporated with Anti‐Inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis |
| title_sort | injectable magnetic hydrogel incorporated with anti inflammatory peptide for efficient magnetothermal treatment of endometriosis |
| topic | anti‐inflammatory therapy drug release endometriosis injectable hydrogel magnetothermal treatment |
| url | https://doi.org/10.1002/advs.202409778 |
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