The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Currently, there is still lack of curative treatment for MS. Mesenchymal stem cell- (MSC-) based therapy is recently the subject of intense interest in autoimmune diseases. Here, we investigated...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5083797 |
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| author | Jun Shu Xiaojuan He Hong Li Xue Liu Xuemei Qiu Tongliang Zhou Ping Wang Xiaojie Huang |
| author_facet | Jun Shu Xiaojuan He Hong Li Xue Liu Xuemei Qiu Tongliang Zhou Ping Wang Xiaojie Huang |
| author_sort | Jun Shu |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Currently, there is still lack of curative treatment for MS. Mesenchymal stem cell- (MSC-) based therapy is recently the subject of intense interest in autoimmune diseases. Here, we investigated the therapeutic effect and potential mechanism of human amnion mesenchymal cells (hAMC) on inflammation and remyelination in experimental autoimmune encephalomyelitis (EAE) mice. C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. hAMC were injected intraperitoneal when EAE was successfully established. The results demonstrated that application of hAMC significantly ameliorated the disease severity and histopathological changes in EAE mice. The production of proinflammatory cytokines such as IFN-γ, TNF-α, IL-1β, and IL-17A in the spleen and CNS was dramatically inhibited. Moreover, CD4+ T cells and CD8+ T cells in the CNS were also significantly decreased in EAE mice after hAMC treatment. In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice. In conclusion, these results indicated that hAMC could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS. |
| format | Article |
| id | doaj-art-035e8434c18544848f09c25dc71c88fa |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-035e8434c18544848f09c25dc71c88fa2025-02-03T05:59:34ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/50837975083797The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE MiceJun Shu0Xiaojuan He1Hong Li2Xue Liu3Xuemei Qiu4Tongliang Zhou5Ping Wang6Xiaojie Huang7Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaInstitute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaMultiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Currently, there is still lack of curative treatment for MS. Mesenchymal stem cell- (MSC-) based therapy is recently the subject of intense interest in autoimmune diseases. Here, we investigated the therapeutic effect and potential mechanism of human amnion mesenchymal cells (hAMC) on inflammation and remyelination in experimental autoimmune encephalomyelitis (EAE) mice. C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. hAMC were injected intraperitoneal when EAE was successfully established. The results demonstrated that application of hAMC significantly ameliorated the disease severity and histopathological changes in EAE mice. The production of proinflammatory cytokines such as IFN-γ, TNF-α, IL-1β, and IL-17A in the spleen and CNS was dramatically inhibited. Moreover, CD4+ T cells and CD8+ T cells in the CNS were also significantly decreased in EAE mice after hAMC treatment. In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice. In conclusion, these results indicated that hAMC could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS.http://dx.doi.org/10.1155/2018/5083797 |
| spellingShingle | Jun Shu Xiaojuan He Hong Li Xue Liu Xuemei Qiu Tongliang Zhou Ping Wang Xiaojie Huang The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice Journal of Immunology Research |
| title | The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice |
| title_full | The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice |
| title_fullStr | The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice |
| title_full_unstemmed | The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice |
| title_short | The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice |
| title_sort | beneficial effect of human amnion mesenchymal cells in inhibition of inflammation and induction of neuronal repair in eae mice |
| url | http://dx.doi.org/10.1155/2018/5083797 |
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