Impact of Diabetes on Cardiovascular Disease: An Update
Cardiovascular diseases are the most prevalent cause of morbidity and mortality among patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated atherosclerosis and increased cardiovascular risk in this population are poorly understood. It has been suggested that an a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/653789 |
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| author | Alessandra Saldanha de Mattos Matheus Lucianne Righeti Monteiro Tannus Roberta Arnoldi Cobas Catia C. Sousa Palma Carlos Antonio Negrato Marilia de Brito Gomes |
| author_facet | Alessandra Saldanha de Mattos Matheus Lucianne Righeti Monteiro Tannus Roberta Arnoldi Cobas Catia C. Sousa Palma Carlos Antonio Negrato Marilia de Brito Gomes |
| author_sort | Alessandra Saldanha de Mattos Matheus |
| collection | DOAJ |
| description | Cardiovascular diseases are the most prevalent cause of morbidity and mortality among patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated atherosclerosis and increased cardiovascular risk in this population are poorly understood. It has been suggested that an association between hyperglycemia and intracellular metabolic changes can result in oxidative stress, low-grade inflammation, and endothelial dysfunction. Recently, epigenetic factors by different types of reactions are known to be responsible for the interaction between genes and environment and for this reason can also account for the association between diabetes and cardiovascular disease. The impact of clinical factors that may coexist with diabetes such as obesity, dyslipidemia, and hypertension are also discussed. Furthermore, evidence that justify screening for subclinical atherosclerosis in asymptomatic patients is controversial and is also matter of this review. The purpose of this paper is to describe the association between poor glycemic control, oxidative stress, markers of insulin resistance, and of low-grade inflammation that have been suggested as putative factors linking diabetes and cardiovascular disease. |
| format | Article |
| id | doaj-art-0354debd099f4da49e8540fef53f4177 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-0354debd099f4da49e8540fef53f41772025-02-03T01:27:44ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/653789653789Impact of Diabetes on Cardiovascular Disease: An UpdateAlessandra Saldanha de Mattos Matheus0Lucianne Righeti Monteiro Tannus1Roberta Arnoldi Cobas2Catia C. Sousa Palma3Carlos Antonio Negrato4Marilia de Brito Gomes5Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Internal Medicine, Bauru's Diabetics Association, Rua Saint Martin 27-07, 17.012-433 Bauru, SP, BrazilDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Avenida 28 de Setembro 77, Terceiro Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilCardiovascular diseases are the most prevalent cause of morbidity and mortality among patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated atherosclerosis and increased cardiovascular risk in this population are poorly understood. It has been suggested that an association between hyperglycemia and intracellular metabolic changes can result in oxidative stress, low-grade inflammation, and endothelial dysfunction. Recently, epigenetic factors by different types of reactions are known to be responsible for the interaction between genes and environment and for this reason can also account for the association between diabetes and cardiovascular disease. The impact of clinical factors that may coexist with diabetes such as obesity, dyslipidemia, and hypertension are also discussed. Furthermore, evidence that justify screening for subclinical atherosclerosis in asymptomatic patients is controversial and is also matter of this review. The purpose of this paper is to describe the association between poor glycemic control, oxidative stress, markers of insulin resistance, and of low-grade inflammation that have been suggested as putative factors linking diabetes and cardiovascular disease.http://dx.doi.org/10.1155/2013/653789 |
| spellingShingle | Alessandra Saldanha de Mattos Matheus Lucianne Righeti Monteiro Tannus Roberta Arnoldi Cobas Catia C. Sousa Palma Carlos Antonio Negrato Marilia de Brito Gomes Impact of Diabetes on Cardiovascular Disease: An Update International Journal of Hypertension |
| title | Impact of Diabetes on Cardiovascular Disease: An Update |
| title_full | Impact of Diabetes on Cardiovascular Disease: An Update |
| title_fullStr | Impact of Diabetes on Cardiovascular Disease: An Update |
| title_full_unstemmed | Impact of Diabetes on Cardiovascular Disease: An Update |
| title_short | Impact of Diabetes on Cardiovascular Disease: An Update |
| title_sort | impact of diabetes on cardiovascular disease an update |
| url | http://dx.doi.org/10.1155/2013/653789 |
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