Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis
Breast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5962946 |
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| author | Monika Zajkowska Edyta Katarzyna Głażewska Grażyna Ewa Będkowska Przemysław Chorąży Maciej Szmitkowski Sławomir Ławicki |
| author_facet | Monika Zajkowska Edyta Katarzyna Głażewska Grażyna Ewa Będkowska Przemysław Chorąży Maciej Szmitkowski Sławomir Ławicki |
| author_sort | Monika Zajkowska |
| collection | DOAJ |
| description | Breast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation. We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women). Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA. VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC. VEGF was also the only parameter which has statistically significant AUC in all stages of cancer. M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC. These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC. Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases. |
| format | Article |
| id | doaj-art-0352c0c8ea9749d9a65443a91955ad35 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0352c0c8ea9749d9a65443a91955ad352025-02-03T01:21:14ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/59629465962946Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC AnalysisMonika Zajkowska0Edyta Katarzyna Głażewska1Grażyna Ewa Będkowska2Przemysław Chorąży3Maciej Szmitkowski4Sławomir Ławicki5Department of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Esthetic Medicine, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Hematological Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Surgery, Public Health Hospital, 19-100 Monki, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandBreast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation. We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women). Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA. VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC. VEGF was also the only parameter which has statistically significant AUC in all stages of cancer. M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC. These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC. Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases.http://dx.doi.org/10.1155/2016/5962946 |
| spellingShingle | Monika Zajkowska Edyta Katarzyna Głażewska Grażyna Ewa Będkowska Przemysław Chorąży Maciej Szmitkowski Sławomir Ławicki Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis Mediators of Inflammation |
| title | Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis |
| title_full | Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis |
| title_fullStr | Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis |
| title_full_unstemmed | Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis |
| title_short | Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis |
| title_sort | diagnostic power of vascular endothelial growth factor and macrophage colony stimulating factor in breast cancer patients based on roc analysis |
| url | http://dx.doi.org/10.1155/2016/5962946 |
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