Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations
Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. Objective: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method: CSF and plasma were c...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2014-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700500&lng=en&tlng=en |
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| _version_ | 1849305248178372608 |
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| author | Sérgio Monteiro de Almeida Jennifer Marquie-Beck Archana Bhatt Scott Letendre Allen McCutchan Ron Ellis |
| author_facet | Sérgio Monteiro de Almeida Jennifer Marquie-Beck Archana Bhatt Scott Letendre Allen McCutchan Ron Ellis |
| author_sort | Sérgio Monteiro de Almeida |
| collection | DOAJ |
| description | Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. Objective: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend® portable analyzer were compared to those tested by a reference device (SYNCHRON LX® 20). Results: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. Conclusions: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a “false positive test”, and should be confirmed by the reference device before concluding abnormality. |
| format | Article |
| id | doaj-art-033fb54d73af4600a364786f78aebdcd |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2014-07-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-033fb54d73af4600a364786f78aebdcd2025-08-20T03:55:32ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272014-07-0172750050510.1590/0004-282X20140076S0004-282X2014000700500Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluationsSérgio Monteiro de AlmeidaJennifer Marquie-BeckArchana BhattScott LetendreAllen McCutchanRon EllisIncreased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. Objective: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. Method: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend® portable analyzer were compared to those tested by a reference device (SYNCHRON LX® 20). Results: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. Conclusions: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a “false positive test”, and should be confirmed by the reference device before concluding abnormality.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700500&lng=en&tlng=enHIVlíquido cefalorraquidianoquímica clínicalactato |
| spellingShingle | Sérgio Monteiro de Almeida Jennifer Marquie-Beck Archana Bhatt Scott Letendre Allen McCutchan Ron Ellis Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations Arquivos de Neuro-Psiquiatria HIV líquido cefalorraquidiano química clínica lactato |
| title | Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations |
| title_full | Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations |
| title_fullStr | Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations |
| title_full_unstemmed | Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations |
| title_short | Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma ? method-comparison evaluations |
| title_sort | portable lactate analyzer for measuring lactate in cerebrospinal fluid csf and plasma method comparison evaluations |
| topic | HIV líquido cefalorraquidiano química clínica lactato |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700500&lng=en&tlng=en |
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