Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer
AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we c...
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| Language: | English |
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BioMed Central
2012-09-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-10-167.pdf |
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| author | Jae Sook Sung Kyong Hwa Park Seung Tae Kim Yeul Hong Kim |
| author_facet | Jae Sook Sung Kyong Hwa Park Seung Tae Kim Yeul Hong Kim |
| author_sort | Jae Sook Sung |
| collection | DOAJ |
| description | AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we confirmed 6 known polymorphisms (AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, AKT3 -675 A/-, and AKT3 -244 C/T) of the AKT2 and AKT3 promoter region in 24 blood samples of Korean lung cancer patients using direct sequencing. To evaluate the role of AKT2 and AKT3 polymorphisms in the risk of Korean lung cancer, genotypes of the AKT2 and AKT3 polymorphisms (AKT2 -9826 C/G, AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, and AKT3 -675 A/-) were determined in 360 lung cancer patients and 360 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the AKT2 and AKT3 promoter regions were not significantly associated with the risk of lung cancer in the Korean population. These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population. |
| format | Article |
| id | doaj-art-0339f5e404e74935820811ff460d46ab |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-0339f5e404e74935820811ff460d46ab2025-02-02T22:50:59ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-09-0110316717410.5808/GI.2012.10.3.16710Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung CancerJae Sook Sung0Kyong Hwa Park1Seung Tae Kim2Yeul Hong Kim3Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul 136-705, Korea.Division of Oncology/Hematology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-701, Korea.Division of Oncology/Hematology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 136-701, Korea.Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul 136-705, Korea.AKT is a signal transduction protein that plays a central role in the tumorigenesis. There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. We first discovered 2 novel polymorphisms (AKT2 -9826 C/G and AKT3 -811 A/G), and we confirmed 6 known polymorphisms (AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, AKT3 -675 A/-, and AKT3 -244 C/T) of the AKT2 and AKT3 promoter region in 24 blood samples of Korean lung cancer patients using direct sequencing. To evaluate the role of AKT2 and AKT3 polymorphisms in the risk of Korean lung cancer, genotypes of the AKT2 and AKT3 polymorphisms (AKT2 -9826 C/G, AKT2 -9473 C/T, AKT2 -9151 C/T, AKT2 -9025 C/T, AKT2 -8618G/A, and AKT3 -675 A/-) were determined in 360 lung cancer patients and 360 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the AKT2 and AKT3 promoter regions were not significantly associated with the risk of lung cancer in the Korean population. These results suggest that polymorphisms of the AKT2 and AKT3 promoter regions do not contribute to the genetic susceptibility to lung cancer in the Korean population.http://genominfo.org/upload/pdf/gni-10-167.pdfAKTgenetic polymorphismgenetic promoter regionlung neoplasms |
| spellingShingle | Jae Sook Sung Kyong Hwa Park Seung Tae Kim Yeul Hong Kim Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer Genomics & Informatics AKT genetic polymorphism genetic promoter region lung neoplasms |
| title | Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer |
| title_full | Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer |
| title_fullStr | Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer |
| title_full_unstemmed | Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer |
| title_short | Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer |
| title_sort | discovery and evaluation of polymorphisms in the and promoter regions for risk of korean lung cancer |
| topic | AKT genetic polymorphism genetic promoter region lung neoplasms |
| url | http://genominfo.org/upload/pdf/gni-10-167.pdf |
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