Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate
Aims. To determine whether a new QTc calculation based on a Spline fit model derived and validated from a large population remained stable in the same individual across a range of heart rates (HRs). Second, to determine whether this formula incorporating QRS duration can be of value in QT measuremen...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/2052601 |
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| author | Hirmand Nouraei Matthew Bennett Simon Rabkin |
| author_facet | Hirmand Nouraei Matthew Bennett Simon Rabkin |
| author_sort | Hirmand Nouraei |
| collection | DOAJ |
| description | Aims. To determine whether a new QTc calculation based on a Spline fit model derived and validated from a large population remained stable in the same individual across a range of heart rates (HRs). Second, to determine whether this formula incorporating QRS duration can be of value in QT measurement, compared to direct measurement of the JT interval, during ventricular pacing. Methods. Individuals (N=30; 14 males) aged 51.9 ± 14.3 years were paced with decremental atrial followed by decremental ventricular pacing. Results. The new QTc changed minimally with shorter RR intervals, poorly fit even a linear relationship, and did not fit a second-order polynomial. In contrast, the Bazett formula (QTcBZT) showed a steep and marked increase in QTc with shorter RR intervals. For atrial pacing data, QTcBZT was fit best by a second-order polynomial and demonstrated a dramatic increase in QTc with progressively shorter RR intervals. For ventricular pacing, the new QTc minus QRS duration did not meaningfully change with HR in contrast to the HR dependency of QTcBZT and JT interval. Conclusion. The new QT correction formula is minimally impacted by HR acceleration induced by atrial or ventricular pacing. The Spline QTc minus QRS duration is an excellent method to estimate QTc in ventricular paced complexes. |
| format | Article |
| id | doaj-art-032e036d28804935a7c1730c3a5b0c6e |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-032e036d28804935a7c1730c3a5b0c6e2025-02-03T01:22:11ZengWileyCardiology Research and Practice2090-80162090-05972018-01-01201810.1155/2018/20526012052601Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart RateHirmand Nouraei0Matthew Bennett1Simon Rabkin2Department of Medicine (Cardiology), University of British Columbia, Vancouver, BC, CanadaDepartment of Medicine (Cardiology), University of British Columbia, Vancouver, BC, CanadaDepartment of Medicine (Cardiology), University of British Columbia, Vancouver, BC, CanadaAims. To determine whether a new QTc calculation based on a Spline fit model derived and validated from a large population remained stable in the same individual across a range of heart rates (HRs). Second, to determine whether this formula incorporating QRS duration can be of value in QT measurement, compared to direct measurement of the JT interval, during ventricular pacing. Methods. Individuals (N=30; 14 males) aged 51.9 ± 14.3 years were paced with decremental atrial followed by decremental ventricular pacing. Results. The new QTc changed minimally with shorter RR intervals, poorly fit even a linear relationship, and did not fit a second-order polynomial. In contrast, the Bazett formula (QTcBZT) showed a steep and marked increase in QTc with shorter RR intervals. For atrial pacing data, QTcBZT was fit best by a second-order polynomial and demonstrated a dramatic increase in QTc with progressively shorter RR intervals. For ventricular pacing, the new QTc minus QRS duration did not meaningfully change with HR in contrast to the HR dependency of QTcBZT and JT interval. Conclusion. The new QT correction formula is minimally impacted by HR acceleration induced by atrial or ventricular pacing. The Spline QTc minus QRS duration is an excellent method to estimate QTc in ventricular paced complexes.http://dx.doi.org/10.1155/2018/2052601 |
| spellingShingle | Hirmand Nouraei Matthew Bennett Simon Rabkin Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate Cardiology Research and Practice |
| title | Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate |
| title_full | Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate |
| title_fullStr | Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate |
| title_full_unstemmed | Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate |
| title_short | Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate |
| title_sort | value of the new spline qtc formula in adjusting for pacing induced changes in heart rate |
| url | http://dx.doi.org/10.1155/2018/2052601 |
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