Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters

Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribu...

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Bibliographic Details
Main Authors: Katherine J. P. Schwenger, Julia K. Copeland, Yasaman Ghorbani, Lina Chen, Elena M. Comelli, David S. Guttman, Sandra E. Fischer, Timothy D. Jackson, Allan Okrainec, Johane P. Allard
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Microbiome
Subjects:
Fatty liver
Tissue microbiome
Hepatic immune cells
Hepatic transcriptome
Adipose gene expression
Online Access:https://doi.org/10.1186/s40168-024-02004-7
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