Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367
We previously reported that propofol upregulated the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) via peroxisome proliferator-activated receptor gamma/liver X receptor in macrophage-derived foam cells. Here, we provide evidence that in addition to inducing ABCA1 expres...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/8907143 |
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| _version_ | 1832551576901779456 |
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| author | Xin Ma Teng Wang Zhen-Long Zhao Yu Jiang Shu Ye |
| author_facet | Xin Ma Teng Wang Zhen-Long Zhao Yu Jiang Shu Ye |
| author_sort | Xin Ma |
| collection | DOAJ |
| description | We previously reported that propofol upregulated the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) via peroxisome proliferator-activated receptor gamma/liver X receptor in macrophage-derived foam cells. Here, we provide evidence that in addition to inducing ABCA1 expression, propofol represses proinflammatory cytokine production by increasing ABCA1 expression in a LOC286367-dependent manner. Western blot analysis showed that ABCA1 expression was elevated in macrophages by propofol treatment and this effect was markedly reduced by LOC286367 overexpression. Moreover, propofol treatment downregulated the production of the proinflammatory cytokines interleukin-6, tumor necrosis factor, and interferon gamma in lipopolysaccharide-stimulated macrophages by enhancing ABCA1 expression. Notably, propofol achieved this effect in a LOC286367-dependent manner. To the best of our knowledge, this is the first report of the mechanism in which propofol represses proinflammatory cytokine production mediated by ABCA1. |
| format | Article |
| id | doaj-art-031d96f6b87040988b9babec0fe34337 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-031d96f6b87040988b9babec0fe343372025-02-03T06:01:06ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/89071438907143Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367Xin Ma0Teng Wang1Zhen-Long Zhao2Yu Jiang3Shu Ye4Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UKWe previously reported that propofol upregulated the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) via peroxisome proliferator-activated receptor gamma/liver X receptor in macrophage-derived foam cells. Here, we provide evidence that in addition to inducing ABCA1 expression, propofol represses proinflammatory cytokine production by increasing ABCA1 expression in a LOC286367-dependent manner. Western blot analysis showed that ABCA1 expression was elevated in macrophages by propofol treatment and this effect was markedly reduced by LOC286367 overexpression. Moreover, propofol treatment downregulated the production of the proinflammatory cytokines interleukin-6, tumor necrosis factor, and interferon gamma in lipopolysaccharide-stimulated macrophages by enhancing ABCA1 expression. Notably, propofol achieved this effect in a LOC286367-dependent manner. To the best of our knowledge, this is the first report of the mechanism in which propofol represses proinflammatory cytokine production mediated by ABCA1.http://dx.doi.org/10.1155/2018/8907143 |
| spellingShingle | Xin Ma Teng Wang Zhen-Long Zhao Yu Jiang Shu Ye Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 Mediators of Inflammation |
| title | Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 |
| title_full | Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 |
| title_fullStr | Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 |
| title_full_unstemmed | Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 |
| title_short | Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367 |
| title_sort | propofol suppresses proinflammatory cytokine production by increasing abca1 expression via mediation by the long noncoding rna loc286367 |
| url | http://dx.doi.org/10.1155/2018/8907143 |
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