The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives
More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance t...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3234906 |
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| author | Elaine Y. Cheng |
| author_facet | Elaine Y. Cheng |
| author_sort | Elaine Y. Cheng |
| collection | DOAJ |
| description | More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance to cell-mediated as well as antibody-mediated rejection. Nevertheless, the protection against alloimmunity is not complete, and antibody-mediated tissue injury can occur in the liver graft under specific circumstances. In this article the evidence on the clinicopathologic effects of donor-specific alloantibodies in liver transplantation will be examined and interpreted in parallel with lessons learned from renal transplantation. The unique anatomic and immunologic features of the liver will be reviewed to gain new insights into the complex interactions between humoral immune system and the liver allograft. |
| format | Article |
| id | doaj-art-03175a1c26a04784a69812cb3a0ce29f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-03175a1c26a04784a69812cb3a0ce29f2025-02-03T06:44:16ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/32349063234906The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New PerspectivesElaine Y. Cheng0Terasaki Foundation Laboratory, Los Angeles, CA, USAMore than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance to cell-mediated as well as antibody-mediated rejection. Nevertheless, the protection against alloimmunity is not complete, and antibody-mediated tissue injury can occur in the liver graft under specific circumstances. In this article the evidence on the clinicopathologic effects of donor-specific alloantibodies in liver transplantation will be examined and interpreted in parallel with lessons learned from renal transplantation. The unique anatomic and immunologic features of the liver will be reviewed to gain new insights into the complex interactions between humoral immune system and the liver allograft.http://dx.doi.org/10.1155/2017/3234906 |
| spellingShingle | Elaine Y. Cheng The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives Journal of Immunology Research |
| title | The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives |
| title_full | The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives |
| title_fullStr | The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives |
| title_full_unstemmed | The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives |
| title_short | The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives |
| title_sort | role of humoral alloreactivity in liver transplantation lessons learned and new perspectives |
| url | http://dx.doi.org/10.1155/2017/3234906 |
| work_keys_str_mv | AT elaineycheng theroleofhumoralalloreactivityinlivertransplantationlessonslearnedandnewperspectives AT elaineycheng roleofhumoralalloreactivityinlivertransplantationlessonslearnedandnewperspectives |