The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study
Abstract This study evaluates the diagnostic performance of two-dimensional shear wave elastography (2D-SWE) in differentiating between benign, metastatic lymph nodes (LNs) and lymphomas. From May 2022 to February 2023, a total of 137 patients who presented with unexplained LN enlargement were exami...
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Nature Portfolio
2025-05-01
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| author | Jing Chen Yao Deng Jiajia Xiong WenQu Li Gongqun Shang Hui Li Yu Wu Xiaojuan Qin |
| author_facet | Jing Chen Yao Deng Jiajia Xiong WenQu Li Gongqun Shang Hui Li Yu Wu Xiaojuan Qin |
| author_sort | Jing Chen |
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| description | Abstract This study evaluates the diagnostic performance of two-dimensional shear wave elastography (2D-SWE) in differentiating between benign, metastatic lymph nodes (LNs) and lymphomas. From May 2022 to February 2023, a total of 137 patients who presented with unexplained LN enlargement were examined at the Ultrasound Medical Department of Union Hospital of Huazhong University of Science and Technology. The conventional ultrasound recorded the location, longitudinal diameter, transverse diameter, L/T ratio, blood supply mode, lymphatic hilum and 2D-SWE calculated the average elasticity (E) of LN. Histopathology was the diagnostic gold standard. A total of 124 patients with 159 superficial LNs were included (32 benign, 70 metastatic, 57 lymphoma). Malignant LNs had significantly higher E values than benign ones (49.38 ± 29.96 kPa vs. 25.00 ± 14.42 kPa, P < 0.001). When E > 25.46 kPa, the AUC, sensitivity, specificity, PPV, NPV and accuracy were 0.807, 0.787, 0.750, 0.926, 0.471 and 0.780, respectively, in identifying malignant LNs. For distinguishing benign LNs from lymphoma, the E cutoff was 25.03 kPa, with the AUC, sensitivity, specificity, PPV, NPV and accuracy of 0.727, 0.754, 0.719, 0.827, 0.622 and 0.742, respectively. To differentiate benign from metastatic LNs, an E cutoff of 36.97 kPa yielded an AUC, sensitivity, specificity, PPV, NPV and accuracy of 0.872, 0.757, 0.875, 0.930, 0.622 and 0.794, respectively. Comparing lymphoma and metastatic LNs, the E cutoff was 42.57 kPa. And the AUC, sensitivity, specificity, PPV, NPV and accuracy were 0.787, 0.700, 0.860, 0.860, 0.700 and 0.772, respectively. 2D-SWE parameter (the average elasticity) can effectively evaluate benign, metastatic LNs and lymphoma, which provides valuable information for preoperative evaluation of superficial LNs. |
| format | Article |
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| institution | DOAJ |
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| language | English |
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| spelling | doaj-art-0301ac61d60a4e91b5a643af34f8604b2025-08-20T03:08:25ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-00502-8The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective studyJing Chen0Yao Deng1Jiajia Xiong2WenQu Li3Gongqun Shang4Hui Li5Yu Wu6Xiaojuan Qin7Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract This study evaluates the diagnostic performance of two-dimensional shear wave elastography (2D-SWE) in differentiating between benign, metastatic lymph nodes (LNs) and lymphomas. From May 2022 to February 2023, a total of 137 patients who presented with unexplained LN enlargement were examined at the Ultrasound Medical Department of Union Hospital of Huazhong University of Science and Technology. The conventional ultrasound recorded the location, longitudinal diameter, transverse diameter, L/T ratio, blood supply mode, lymphatic hilum and 2D-SWE calculated the average elasticity (E) of LN. Histopathology was the diagnostic gold standard. A total of 124 patients with 159 superficial LNs were included (32 benign, 70 metastatic, 57 lymphoma). Malignant LNs had significantly higher E values than benign ones (49.38 ± 29.96 kPa vs. 25.00 ± 14.42 kPa, P < 0.001). When E > 25.46 kPa, the AUC, sensitivity, specificity, PPV, NPV and accuracy were 0.807, 0.787, 0.750, 0.926, 0.471 and 0.780, respectively, in identifying malignant LNs. For distinguishing benign LNs from lymphoma, the E cutoff was 25.03 kPa, with the AUC, sensitivity, specificity, PPV, NPV and accuracy of 0.727, 0.754, 0.719, 0.827, 0.622 and 0.742, respectively. To differentiate benign from metastatic LNs, an E cutoff of 36.97 kPa yielded an AUC, sensitivity, specificity, PPV, NPV and accuracy of 0.872, 0.757, 0.875, 0.930, 0.622 and 0.794, respectively. Comparing lymphoma and metastatic LNs, the E cutoff was 42.57 kPa. And the AUC, sensitivity, specificity, PPV, NPV and accuracy were 0.787, 0.700, 0.860, 0.860, 0.700 and 0.772, respectively. 2D-SWE parameter (the average elasticity) can effectively evaluate benign, metastatic LNs and lymphoma, which provides valuable information for preoperative evaluation of superficial LNs.https://doi.org/10.1038/s41598-025-00502-8UltrasoundShear-wave elastographySuperficial lymph nodesDifferential diagnosis |
| spellingShingle | Jing Chen Yao Deng Jiajia Xiong WenQu Li Gongqun Shang Hui Li Yu Wu Xiaojuan Qin The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study Scientific Reports Ultrasound Shear-wave elastography Superficial lymph nodes Differential diagnosis |
| title | The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study |
| title_full | The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study |
| title_fullStr | The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study |
| title_full_unstemmed | The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study |
| title_short | The diagnostic value of two-dimensional shear-wave elastography in identifying malignant lesions in lymph nodes: a prospective study |
| title_sort | diagnostic value of two dimensional shear wave elastography in identifying malignant lesions in lymph nodes a prospective study |
| topic | Ultrasound Shear-wave elastography Superficial lymph nodes Differential diagnosis |
| url | https://doi.org/10.1038/s41598-025-00502-8 |
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