Maprotiline inhibits COX2 and iNOS gene expression in lipopolysaccharide-stimulated U937 macrophages and carrageenan-induced paw edema in rats

Maprotiline inhibits COX2 and iNOS gene expression in lipopolysaccharide-stimulated U937 macrophages and carrageenan-induced paw edema in rats

Maprotiline, a tetracyclic antidepressant, is used for the management of mental disorders and various types of chronic pain. In our previous work, we found the inhibitory effect of maprotiline on inflammatory mediator’s expression like tumor necrosis factor  (TNF-) and interleukin 1β (IL-1β). As p...

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Bibliographic Details
Main Authors: Laleh Rafiee, Valiollah Hajhashemi, Shaghayegh Haghjooy Javanmard
Format: Article
Language:English
Published: Termedia Publishing House 2019-04-01
Series:Central European Journal of Immunology
Subjects:
maprotiline
inflammation
cox2
inos
Online Access:https://www.termedia.pl/Maprotiline-inhibits-COX2-and-iNOS-gene-expression-in-lipopolysaccharide-stimulated-U937-macrophages-and-carrageenan-induced-paw-edema-in-rats,10,36200,1,1.html
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