Imidazole: Having Versatile Biological Activities
Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutic...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/329412 |
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| author | Amita Verma Sunil Joshi Deepika Singh |
| author_facet | Amita Verma Sunil Joshi Deepika Singh |
| author_sort | Amita Verma |
| collection | DOAJ |
| description | Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of imidazole-containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of imidazole during the past years. |
| format | Article |
| id | doaj-art-02faab940d5342179b8d81f614d924fb |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-02faab940d5342179b8d81f614d924fb2025-02-03T05:58:39ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/329412329412Imidazole: Having Versatile Biological ActivitiesAmita Verma0Sunil Joshi1Deepika Singh2Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (Deemed to be University), Allahabad, Uttar Pradesh 211007, IndiaDepartment of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (Deemed to be University), Allahabad, Uttar Pradesh 211007, IndiaDepartment of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (Deemed to be University), Allahabad, Uttar Pradesh 211007, IndiaImidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of imidazole-containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of imidazole during the past years.http://dx.doi.org/10.1155/2013/329412 |
| spellingShingle | Amita Verma Sunil Joshi Deepika Singh Imidazole: Having Versatile Biological Activities Journal of Chemistry |
| title | Imidazole: Having Versatile Biological Activities |
| title_full | Imidazole: Having Versatile Biological Activities |
| title_fullStr | Imidazole: Having Versatile Biological Activities |
| title_full_unstemmed | Imidazole: Having Versatile Biological Activities |
| title_short | Imidazole: Having Versatile Biological Activities |
| title_sort | imidazole having versatile biological activities |
| url | http://dx.doi.org/10.1155/2013/329412 |
| work_keys_str_mv | AT amitaverma imidazolehavingversatilebiologicalactivities AT suniljoshi imidazolehavingversatilebiologicalactivities AT deepikasingh imidazolehavingversatilebiologicalactivities |