Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears
Abstrct Rotator cuff injury (RCI), characterized by shoulder pain and restricted mobility, represents a subset of tendon-bone insertion injuries (TBI). In the majority of cases, surgical reconstruction of the affected tendons or ligaments is required to address the damage. However, numerous clinical...
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| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06029-2 |
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| author | Junjie Chen Zihe Wang Ming Yi Yi Yang Mengzhao Tian Yinqi Liu Guoyou Wang Huarui Shen |
| author_facet | Junjie Chen Zihe Wang Ming Yi Yi Yang Mengzhao Tian Yinqi Liu Guoyou Wang Huarui Shen |
| author_sort | Junjie Chen |
| collection | DOAJ |
| description | Abstrct Rotator cuff injury (RCI), characterized by shoulder pain and restricted mobility, represents a subset of tendon-bone insertion injuries (TBI). In the majority of cases, surgical reconstruction of the affected tendons or ligaments is required to address the damage. However, numerous clinical failures have underscored the suboptimal outcomes associated with such procedures. Further investigations have revealed that these failures are largely attributable to delayed healing at the tendon-bone interface, excessive formation of vascularized scar tissue, and inadequate integration of tendon grafts within bone tunnels. As a result, the healing process of rotator cuff injuries faces significant challenges.Bone marrow-derived mesenchymal stem cell exosomes (BMSC-exos) have emerged as a prominent focus of research within the field of bioengineering, owing to their remarkable potential to regulate cellular proliferation and differentiation, modulate immune responses, and facilitate tissue repair and regeneration following cellular damage. In this review, we explore the anti-inflammatory, angiogenic, anti-scarring, and bone metabolism-modulating effects of BMSC-exos in the context of rotator cuff injury. Additionally, we address the limitations and ongoing challenges within current research, offering insights that could guide the clinical application of BMSC-exos in the treatment of rotator cuff injuries in the future. |
| format | Article |
| id | doaj-art-02f57805474248faa5b200aa6a9944a2 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-02f57805474248faa5b200aa6a9944a22025-01-19T12:37:26ZengBMCJournal of Translational Medicine1479-58762025-01-0123111910.1186/s12967-024-06029-2Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tearsJunjie Chen0Zihe Wang1Ming Yi2Yi Yang3Mengzhao Tian4Yinqi Liu5Guoyou Wang6Huarui Shen7Department of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversitySchool of Materials and Energy, Southwest University, Southwest University HospitalDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityAbstrct Rotator cuff injury (RCI), characterized by shoulder pain and restricted mobility, represents a subset of tendon-bone insertion injuries (TBI). In the majority of cases, surgical reconstruction of the affected tendons or ligaments is required to address the damage. However, numerous clinical failures have underscored the suboptimal outcomes associated with such procedures. Further investigations have revealed that these failures are largely attributable to delayed healing at the tendon-bone interface, excessive formation of vascularized scar tissue, and inadequate integration of tendon grafts within bone tunnels. As a result, the healing process of rotator cuff injuries faces significant challenges.Bone marrow-derived mesenchymal stem cell exosomes (BMSC-exos) have emerged as a prominent focus of research within the field of bioengineering, owing to their remarkable potential to regulate cellular proliferation and differentiation, modulate immune responses, and facilitate tissue repair and regeneration following cellular damage. In this review, we explore the anti-inflammatory, angiogenic, anti-scarring, and bone metabolism-modulating effects of BMSC-exos in the context of rotator cuff injury. Additionally, we address the limitations and ongoing challenges within current research, offering insights that could guide the clinical application of BMSC-exos in the treatment of rotator cuff injuries in the future.https://doi.org/10.1186/s12967-024-06029-2Tendon–bone healingExosomesBone marrow mesenchymal stem cellsRotator cuff regenerativeDrug deliveryNanocarriers |
| spellingShingle | Junjie Chen Zihe Wang Ming Yi Yi Yang Mengzhao Tian Yinqi Liu Guoyou Wang Huarui Shen Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears Journal of Translational Medicine Tendon–bone healing Exosomes Bone marrow mesenchymal stem cells Rotator cuff regenerative Drug delivery Nanocarriers |
| title | Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| title_full | Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| title_fullStr | Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| title_full_unstemmed | Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| title_short | Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| title_sort | regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears |
| topic | Tendon–bone healing Exosomes Bone marrow mesenchymal stem cells Rotator cuff regenerative Drug delivery Nanocarriers |
| url | https://doi.org/10.1186/s12967-024-06029-2 |
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