Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism

Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism

Abstract Background Metabolic Syndrome (MetS), as a syndrome characterized by low-grade inflammation and energy metabolism disorders, is considered to be an important systemic risk factor for knee osteoarthritis (KOA). Our previous study showed that the protein level of serum resistin was positively...

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Main Authors: Lu Ding, Jin-Yi Ren, Yi-Fan Huang, Jian-Zeng Zhang, Zi-Ran Bai, Yi Leng, Jun-Wei Tian, Jing Wei, Min-Li Jin, Guan Wang, Xia Li, Xin Qi
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Arthritis Research & Therapy
Subjects:
Knee osteoarthritis
Metabolic syndrome
Resistin
Fatty acid oxidation
Online Access:https://doi.org/10.1186/s13075-025-03527-6
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https://doi.org/10.1186/s13075-025-03527-6

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