The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy
ABSTRACT Objective To investigate the relationship between four metabolic indices—visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and cholesterol‐HDL‐glucose (CHG) index—and the presence of diabetic nephropathy (DN) and diabetic retinopathy (DR) in...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.70086 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849413072344580096 |
|---|---|
| author | Merve Çatak Şerife Gülhan Konuk Sema Hepsen |
| author_facet | Merve Çatak Şerife Gülhan Konuk Sema Hepsen |
| author_sort | Merve Çatak |
| collection | DOAJ |
| description | ABSTRACT Objective To investigate the relationship between four metabolic indices—visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and cholesterol‐HDL‐glucose (CHG) index—and the presence of diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with long‐standing type 2 diabetes mellitus (T2DM). Materials and Methods This prospective cross‐sectional study included 175 T2DM patients with disease duration >10 years who attended an endocrinology outpatient clinic between July 2021 and January 2022. DR was assessed via fundus photography, and DN was defined using the urinary albumin‐to‐creatinine ratio and eGFR. VAI, LAP, TyG, and CHG indices were calculated using anthropometric and biochemical parameters. Logistic regression was used to identify independent predictors. Results The mean age was 60 ± 10.1 years; 63.4% were female. DR and DN were observed in 50.3% and 38.9% of patients, respectively. VAI, LAP, and TyG were significantly higher in patients with DN but not with DR. CHG was elevated in both DN and DR (P < 0.05), and was the only independent predictor of DN (P = 0.005). Notably, CHG was significantly higher in proliferative vs non‐proliferative DR (P = 0.009), unlike the other indices. Conclusions While VAI, LAP, and TyG were associated only with nephropathy, CHG was linked to both DN and DR. Its integration of glycemic and lipid parameters may offer greater sensitivity for microvascular risk stratification in T2DM. |
| format | Article |
| id | doaj-art-02dbac84171645f7b50890d00a4e1cb2 |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-02dbac84171645f7b50890d00a4e1cb22025-08-20T03:34:14ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-08-011681487149410.1111/jdi.70086The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathyMerve Çatak0Şerife Gülhan Konuk1Sema Hepsen2Faculty of Medicine, Department of Endocrinology and Metabolism Tokat Gazıosmanpasa University Tokat TurkeyFaculty of Medicine, Department of Opthalmology Tokat Gazıosmanpasa University Tokat TurkeyDepartment of Endocrinology and Metabolism Ankara Etlik City Hospital Ankara TurkeyABSTRACT Objective To investigate the relationship between four metabolic indices—visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, and cholesterol‐HDL‐glucose (CHG) index—and the presence of diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with long‐standing type 2 diabetes mellitus (T2DM). Materials and Methods This prospective cross‐sectional study included 175 T2DM patients with disease duration >10 years who attended an endocrinology outpatient clinic between July 2021 and January 2022. DR was assessed via fundus photography, and DN was defined using the urinary albumin‐to‐creatinine ratio and eGFR. VAI, LAP, TyG, and CHG indices were calculated using anthropometric and biochemical parameters. Logistic regression was used to identify independent predictors. Results The mean age was 60 ± 10.1 years; 63.4% were female. DR and DN were observed in 50.3% and 38.9% of patients, respectively. VAI, LAP, and TyG were significantly higher in patients with DN but not with DR. CHG was elevated in both DN and DR (P < 0.05), and was the only independent predictor of DN (P = 0.005). Notably, CHG was significantly higher in proliferative vs non‐proliferative DR (P = 0.009), unlike the other indices. Conclusions While VAI, LAP, and TyG were associated only with nephropathy, CHG was linked to both DN and DR. Its integration of glycemic and lipid parameters may offer greater sensitivity for microvascular risk stratification in T2DM.https://doi.org/10.1111/jdi.70086Cholesterol‐high density lipoprotein glucoseLipid accumulation productVisceral adiposity index |
| spellingShingle | Merve Çatak Şerife Gülhan Konuk Sema Hepsen The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy Journal of Diabetes Investigation Cholesterol‐high density lipoprotein glucose Lipid accumulation product Visceral adiposity index |
| title | The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| title_full | The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| title_fullStr | The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| title_full_unstemmed | The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| title_short | The cholesterol‐HDL‐glucose (CHG) index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| title_sort | cholesterol hdl glucose chg index and traditional adiposity markers in predicting diabetic retinopathy and nephropathy |
| topic | Cholesterol‐high density lipoprotein glucose Lipid accumulation product Visceral adiposity index |
| url | https://doi.org/10.1111/jdi.70086 |
| work_keys_str_mv | AT mervecatak thecholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy AT serifegulhankonuk thecholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy AT semahepsen thecholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy AT mervecatak cholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy AT serifegulhankonuk cholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy AT semahepsen cholesterolhdlglucosechgindexandtraditionaladipositymarkersinpredictingdiabeticretinopathyandnephropathy |