Role of P-glycoprotein in the pharmacotherapy of pregnant women
This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the transporter function and the hormone fluctuations durin...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-07-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/565 |
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| author | N. M. Popova A. V. Shchulkin I. V. Chernykh A. S. Esenina M. M. Gradinar E. N. Yakusheva |
| author_facet | N. M. Popova A. V. Shchulkin I. V. Chernykh A. S. Esenina M. M. Gradinar E. N. Yakusheva |
| author_sort | N. M. Popova |
| collection | DOAJ |
| description | This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the transporter function and the hormone fluctuations during pregnancy. We cite studies on the association between the MDR1/mdr1 gene polymorphisms and the hemato-placental barrier permeability for Pgp substrates, as well as fetal malformations. Under a separate section, drugs commonly used in pregnant women are characterized in terms of their roles as substrates, inducers or inhibitors of the Pgp transporter. |
| format | Article |
| id | doaj-art-02cc39edd35943f8ba648e22c5958e5e |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-02cc39edd35943f8ba648e22c5958e5e2025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942019-07-0113216417310.17749/2313-7347.2019.13.2.164-173503Role of P-glycoprotein in the pharmacotherapy of pregnant womenN. M. Popova0A. V. Shchulkin1I. V. Chernykh2A. S. Esenina3M. M. Gradinar4E. N. Yakusheva5Ryazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationRyazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationRyazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationRyazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationRyazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationRyazan State Medical University named after Аcademician I.P. Pavlov, Health Ministry of Russian FederationThis review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the transporter function and the hormone fluctuations during pregnancy. We cite studies on the association between the MDR1/mdr1 gene polymorphisms and the hemato-placental barrier permeability for Pgp substrates, as well as fetal malformations. Under a separate section, drugs commonly used in pregnant women are characterized in terms of their roles as substrates, inducers or inhibitors of the Pgp transporter.https://www.gynecology.su/jour/article/view/565p-glycoprotein (pgp)abcb1 transportermdr1 genepregnancypharmacotherapysubstratesinducersinhibitors |
| spellingShingle | N. M. Popova A. V. Shchulkin I. V. Chernykh A. S. Esenina M. M. Gradinar E. N. Yakusheva Role of P-glycoprotein in the pharmacotherapy of pregnant women Акушерство, гинекология и репродукция p-glycoprotein (pgp) abcb1 transporter mdr1 gene pregnancy pharmacotherapy substrates inducers inhibitors |
| title | Role of P-glycoprotein in the pharmacotherapy of pregnant women |
| title_full | Role of P-glycoprotein in the pharmacotherapy of pregnant women |
| title_fullStr | Role of P-glycoprotein in the pharmacotherapy of pregnant women |
| title_full_unstemmed | Role of P-glycoprotein in the pharmacotherapy of pregnant women |
| title_short | Role of P-glycoprotein in the pharmacotherapy of pregnant women |
| title_sort | role of p glycoprotein in the pharmacotherapy of pregnant women |
| topic | p-glycoprotein (pgp) abcb1 transporter mdr1 gene pregnancy pharmacotherapy substrates inducers inhibitors |
| url | https://www.gynecology.su/jour/article/view/565 |
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