Downregulation of the p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation

Downregulation of the p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation

Background/Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic. The disease has a strong genetic component, and a common missense variant (rs2642438) in the mitochondrial amidoxime-reducing component 1 (MARC1) gene confers protection against its onset and sever...

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Main Authors: Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, Lohitesh Kovooru, Francesca R. Noto, Grazia Pennisi, Salvatore Petta, Angela Mirarchi, Samantha Maurotti, Bernardette Scopacasa, Luca Tirinato, Patrizio Candeloro, Marcus Henricsson, Daniel Lindén, Oveis Jamialahmadi, Arturo Pujia, Rosellina M. Mancina, Stefano Romeo
Format: Article
Language:English
Published: Korean Association for the Study of the Liver 2025-04-01
Series:Clinical and Molecular Hepatology
Subjects:
masld
steatohepatitis
mtarc1
fatty acid oxidation
ferroptosis
reactive oxygen species
Online Access:http://e-cmh.org/upload/pdf/cmh-2024-0642.pdf
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http://e-cmh.org/upload/pdf/cmh-2024-0642.pdf

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