Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks
Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimic...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2008/108969 |
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| _version_ | 1832563538811420672 |
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| author | Atsushi Usami Norio Matsuki Yuji Ikegaya |
| author_facet | Atsushi Usami Norio Matsuki Yuji Ikegaya |
| author_sort | Atsushi Usami |
| collection | DOAJ |
| description | Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditions, spontaneous activity was increased in active cell number and activity frequency. When ionic compositions were restored to the control conditions, the activity level returned to baseline, but the weighted spatial dispersion of active cells, as assessed by entropy-based metrics, did not. Thus, the networks can modify themselves by altering the internal structure of their correlated activity, even though they as a whole maintained the same level of activity in space and time. |
| format | Article |
| id | doaj-art-02ca420ae8084149bbe8860694aa5da7 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-02ca420ae8084149bbe8860694aa5da72025-02-03T01:13:07ZengWileyNeural Plasticity2090-59041687-54432008-01-01200810.1155/2008/108969108969Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal NetworksAtsushi Usami0Norio Matsuki1Yuji Ikegaya2Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, JapanUsing functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditions, spontaneous activity was increased in active cell number and activity frequency. When ionic compositions were restored to the control conditions, the activity level returned to baseline, but the weighted spatial dispersion of active cells, as assessed by entropy-based metrics, did not. Thus, the networks can modify themselves by altering the internal structure of their correlated activity, even though they as a whole maintained the same level of activity in space and time.http://dx.doi.org/10.1155/2008/108969 |
| spellingShingle | Atsushi Usami Norio Matsuki Yuji Ikegaya Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks Neural Plasticity |
| title | Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks |
| title_full | Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks |
| title_fullStr | Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks |
| title_full_unstemmed | Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks |
| title_short | Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks |
| title_sort | spontaneous plasticity of multineuronal activity patterns in activated hippocampal networks |
| url | http://dx.doi.org/10.1155/2008/108969 |
| work_keys_str_mv | AT atsushiusami spontaneousplasticityofmultineuronalactivitypatternsinactivatedhippocampalnetworks AT noriomatsuki spontaneousplasticityofmultineuronalactivitypatternsinactivatedhippocampalnetworks AT yujiikegaya spontaneousplasticityofmultineuronalactivitypatternsinactivatedhippocampalnetworks |