Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis
B-cell lymphoma/leukemia 11A (BCL11A) is a crucial transcriptional regulator, widely recognized for its role in controlling fetal hemoglobin and its potential as a gene therapy target for inherited hemoglobinopathies. Beyond this, recent studies have also highlighted its key role in the maturation a...
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2025-01-01
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| author | Haihang Zhang Junhao Zeng Fangling Zhang Jing Liu Long Liang |
| author_facet | Haihang Zhang Junhao Zeng Fangling Zhang Jing Liu Long Liang |
| author_sort | Haihang Zhang |
| collection | DOAJ |
| description | B-cell lymphoma/leukemia 11A (BCL11A) is a crucial transcriptional regulator, widely recognized for its role in controlling fetal hemoglobin and its potential as a gene therapy target for inherited hemoglobinopathies. Beyond this, recent studies have also highlighted its key role in the maturation and function of immune cells and erythrocytes, mediated through the regulation of various molecules during hematopoietic development. The dysregulation of BCL11A disrupts downstream molecular pathways, contributing to the development of several hematological malignancies, particularly leukemias. This review provides a comprehensive overview of the role of BCL11A in normal and malignant hematopoiesis, details the hematological disorders associated with its dysregulation and explores the current therapeutic strategies targeting this transcription factor. |
| format | Article |
| id | doaj-art-02c5c5887cec4ac8805d91538cd21a8c |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-02c5c5887cec4ac8805d91538cd21a8c2025-01-24T13:23:20ZengMDPI AGBiology2079-77372025-01-011412610.3390/biology14010026Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant HematopoiesisHaihang Zhang0Junhao Zeng1Fangling Zhang2Jing Liu3Long Liang4Department of Hematology, the Second Xiangya Hospital, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, ChinaXiangya School of Medicine, Central South University, Changsha 410013, ChinaDepartment of Hematology, the Second Xiangya Hospital, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, ChinaDepartment of Hematology, the Second Xiangya Hospital, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, ChinaDepartment of Hematology, the Second Xiangya Hospital, School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410011, ChinaB-cell lymphoma/leukemia 11A (BCL11A) is a crucial transcriptional regulator, widely recognized for its role in controlling fetal hemoglobin and its potential as a gene therapy target for inherited hemoglobinopathies. Beyond this, recent studies have also highlighted its key role in the maturation and function of immune cells and erythrocytes, mediated through the regulation of various molecules during hematopoietic development. The dysregulation of BCL11A disrupts downstream molecular pathways, contributing to the development of several hematological malignancies, particularly leukemias. This review provides a comprehensive overview of the role of BCL11A in normal and malignant hematopoiesis, details the hematological disorders associated with its dysregulation and explores the current therapeutic strategies targeting this transcription factor.https://www.mdpi.com/2079-7737/14/1/26B-cell lymphoma/leukemia 11Anormal and malignant hematopoiesispotential clinical applicationgene editingmedicine |
| spellingShingle | Haihang Zhang Junhao Zeng Fangling Zhang Jing Liu Long Liang Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis Biology B-cell lymphoma/leukemia 11A normal and malignant hematopoiesis potential clinical application gene editing medicine |
| title | Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis |
| title_full | Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis |
| title_fullStr | Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis |
| title_full_unstemmed | Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis |
| title_short | Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis |
| title_sort | role of b cell lymphoma leukemia 11a in normal and malignant hematopoiesis |
| topic | B-cell lymphoma/leukemia 11A normal and malignant hematopoiesis potential clinical application gene editing medicine |
| url | https://www.mdpi.com/2079-7737/14/1/26 |
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