Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Clearance

Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Clearance

The course and outcome of infection with the parasitic protozoa <i>Leishmania major</i> depends on the host immune response which, itself, depends mainly on the cytokine milieu, especially early in the infection. It is widely accepted that INF-γ, TNF-α, and IL-12 usually favor a protecti...

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Bibliographic Details
Main Authors: Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Microbiology Research
Subjects:
parasitic protozoa
<i>Leishmania major</i>
immunomodulation
cytokine
TNF-α
hyperalgesia
Online Access:https://www.mdpi.com/2036-7481/16/1/8
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