Plant Extracts in the Bone Repair Process: A Systematic Review
Bone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant pr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/1296153 |
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| author | Lyvia Lopes Miranda Vanessa de Paula Guimarães-Lopes Luciana Schulthais Altoé Mariáurea Matias Sarandy Fabiana Cristina Silveira Alves Melo Rômulo Dias Novaes Reggiani Vilela Gonçalves |
| author_facet | Lyvia Lopes Miranda Vanessa de Paula Guimarães-Lopes Luciana Schulthais Altoé Mariáurea Matias Sarandy Fabiana Cristina Silveira Alves Melo Rômulo Dias Novaes Reggiani Vilela Gonçalves |
| author_sort | Lyvia Lopes Miranda |
| collection | DOAJ |
| description | Bone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant products from plants for bone lesion treatment have been growing worldwide. We developed a systematic review to compile the results of works with animal models investigating the anti-inflammatory activity of plant extracts in the treatment of bone lesions and analyze the methodological quality of the studies on this subject. Studies were selected in the PubMed/MEDLINE, Scopus, and Web of Science databases according to the PRISMA statement. The research filters were constructed using three parameters: animal model, bone repair, and plant extracts. 31 full-text articles were recovered from 10 countries. Phytochemical prospecting was reported in 15 studies (48.39%). The most common secondary metabolites were flavonoids, cited in 32.26% studies (n=10). Essential criteria to in vivo animal studies were frequently underreported, suggesting publication bias. The animals treated with plant extracts presented positive results in the osteoblastic proliferation, and consequently, this treatment accelerated osteogenic differentiation and bone callus formation, as well as bone fracture repair. Possibly, these results are associated with antioxidant, regenerative, and anti-inflammatory power of the extracts. The absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impairs the internal validity of the evidence, making it difficult to determine the effectiveness and safety of plant-derived products in bone repair. |
| format | Article |
| id | doaj-art-02ae71dc19e5416b9a5ebf5656b10d64 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-02ae71dc19e5416b9a5ebf5656b10d642025-02-03T05:58:59ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/12961531296153Plant Extracts in the Bone Repair Process: A Systematic ReviewLyvia Lopes Miranda0Vanessa de Paula Guimarães-Lopes1Luciana Schulthais Altoé2Mariáurea Matias Sarandy3Fabiana Cristina Silveira Alves Melo4Rômulo Dias Novaes5Reggiani Vilela Gonçalves6Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilDepartment of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilDepartment of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilDepartment of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilDepartment of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilInstitute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, Alfenas, Minas Gerais 37130-001, BrazilDepartment of Animal Biology, Federal University of Viçosa, Viçosa, Minas Gerais 36570-900, BrazilBone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant products from plants for bone lesion treatment have been growing worldwide. We developed a systematic review to compile the results of works with animal models investigating the anti-inflammatory activity of plant extracts in the treatment of bone lesions and analyze the methodological quality of the studies on this subject. Studies were selected in the PubMed/MEDLINE, Scopus, and Web of Science databases according to the PRISMA statement. The research filters were constructed using three parameters: animal model, bone repair, and plant extracts. 31 full-text articles were recovered from 10 countries. Phytochemical prospecting was reported in 15 studies (48.39%). The most common secondary metabolites were flavonoids, cited in 32.26% studies (n=10). Essential criteria to in vivo animal studies were frequently underreported, suggesting publication bias. The animals treated with plant extracts presented positive results in the osteoblastic proliferation, and consequently, this treatment accelerated osteogenic differentiation and bone callus formation, as well as bone fracture repair. Possibly, these results are associated with antioxidant, regenerative, and anti-inflammatory power of the extracts. The absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impairs the internal validity of the evidence, making it difficult to determine the effectiveness and safety of plant-derived products in bone repair.http://dx.doi.org/10.1155/2019/1296153 |
| spellingShingle | Lyvia Lopes Miranda Vanessa de Paula Guimarães-Lopes Luciana Schulthais Altoé Mariáurea Matias Sarandy Fabiana Cristina Silveira Alves Melo Rômulo Dias Novaes Reggiani Vilela Gonçalves Plant Extracts in the Bone Repair Process: A Systematic Review Mediators of Inflammation |
| title | Plant Extracts in the Bone Repair Process: A Systematic Review |
| title_full | Plant Extracts in the Bone Repair Process: A Systematic Review |
| title_fullStr | Plant Extracts in the Bone Repair Process: A Systematic Review |
| title_full_unstemmed | Plant Extracts in the Bone Repair Process: A Systematic Review |
| title_short | Plant Extracts in the Bone Repair Process: A Systematic Review |
| title_sort | plant extracts in the bone repair process a systematic review |
| url | http://dx.doi.org/10.1155/2019/1296153 |
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