Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis
Introduction Most overweight/obese women with polycystic ovary syndrome (PCOS) have infertility issues which are difficult to treat. Non-pharmacological interventions used for the management of infertility include lifestyle interventions, acupuncture therapies and nutritional supplements. These inte...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-06-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e059090.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586904474746880 |
|---|---|
| author | Juan Li Jie Yang Fan-rong Liang Jun Zhou Gui-Xing Xu Han Yang Yan-qun Xiao Jia-jia Liu Zhi-yong Xiao Xiao-yan Zheng Li-ying Liu Zheng Yu |
| author_facet | Juan Li Jie Yang Fan-rong Liang Jun Zhou Gui-Xing Xu Han Yang Yan-qun Xiao Jia-jia Liu Zhi-yong Xiao Xiao-yan Zheng Li-ying Liu Zheng Yu |
| author_sort | Juan Li |
| collection | DOAJ |
| description | Introduction Most overweight/obese women with polycystic ovary syndrome (PCOS) have infertility issues which are difficult to treat. Non-pharmacological interventions used for the management of infertility include lifestyle interventions, acupuncture therapies and nutritional supplements. These interventions have been reported to be beneficial in alleviating infertility among overweight women with PCOS. However, effect and safety of these non-pharmacological interventions vary, and there is no standard method of clinical application. Therefore, it is necessary to conduct a systematic review and network meta-analysis (NMA) to rank these non-pharmacological interventions in terms of effect and determine which one is more effective for clinical application.Methods and analysis We will retrieve eight databases including Cochrane Library, Medline, Embase, PsycINFO, Chinese National Knowledge Infrastructure, WanFang Data, the Chongqing VIP Database and China Biology Medicine disc from their inceptions onwards. In addition, four clinical trial registries and the related references will be manually retrieved. The primary outcome will be clinical pregnancy. Live birth, ovulation, pregnancy loss, multiple pregnancy and adverse events related to interventions will be considered as the secondary outcomes. STATA software V.15.0 and Aggregate Data Drug Information System V.1.16.8 will be used to conduct pairwise meta-analysis and NMA. The Grading of Recommendations Assessment, Development and Evaluation system will be adopted to evaluate the certainty of evidence.Ethics and dissemination Ethical approval will not be required because the study will not include the original information of participants. The results will be published in a peer-reviewed journal or disseminated in relevant conferences.PROSPERO registration number CRD42021283110. |
| format | Article |
| id | doaj-art-029c336d29eb4d69a386e5e29e6b0ba0 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-029c336d29eb4d69a386e5e29e6b0ba02025-01-24T20:05:08ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-059090Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysisJuan Li0Jie Yang1Fan-rong Liang2Jun Zhou3Gui-Xing Xu4Han Yang5Yan-qun Xiao6Jia-jia Liu7Zhi-yong Xiao8Xiao-yan Zheng9Li-ying Liu10Zheng Yu118 Huashan Hospital affiliated to Fudan University, Shanghai, ChinaDepartment of Neurology, Xinqiao Hospital and the Second Affiliated Hospital of Army Medical University, Chongqing, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Pathology, Shanghai Jiao Tong University Affiliated Sixth People`s Hospital, Shanghai, ChinaAcupuncture and Tuina School / The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine/Clinical Research Center for Acupuncture and Moxibustion in Sichuan province, Chengdu, ChinaHenan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, Henan, ChinaInfertility Clinic, Chengdu Xinan Gynecological Hospital, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCollege of Medical Information and Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaIntroduction Most overweight/obese women with polycystic ovary syndrome (PCOS) have infertility issues which are difficult to treat. Non-pharmacological interventions used for the management of infertility include lifestyle interventions, acupuncture therapies and nutritional supplements. These interventions have been reported to be beneficial in alleviating infertility among overweight women with PCOS. However, effect and safety of these non-pharmacological interventions vary, and there is no standard method of clinical application. Therefore, it is necessary to conduct a systematic review and network meta-analysis (NMA) to rank these non-pharmacological interventions in terms of effect and determine which one is more effective for clinical application.Methods and analysis We will retrieve eight databases including Cochrane Library, Medline, Embase, PsycINFO, Chinese National Knowledge Infrastructure, WanFang Data, the Chongqing VIP Database and China Biology Medicine disc from their inceptions onwards. In addition, four clinical trial registries and the related references will be manually retrieved. The primary outcome will be clinical pregnancy. Live birth, ovulation, pregnancy loss, multiple pregnancy and adverse events related to interventions will be considered as the secondary outcomes. STATA software V.15.0 and Aggregate Data Drug Information System V.1.16.8 will be used to conduct pairwise meta-analysis and NMA. The Grading of Recommendations Assessment, Development and Evaluation system will be adopted to evaluate the certainty of evidence.Ethics and dissemination Ethical approval will not be required because the study will not include the original information of participants. The results will be published in a peer-reviewed journal or disseminated in relevant conferences.PROSPERO registration number CRD42021283110.https://bmjopen.bmj.com/content/12/6/e059090.full |
| spellingShingle | Juan Li Jie Yang Fan-rong Liang Jun Zhou Gui-Xing Xu Han Yang Yan-qun Xiao Jia-jia Liu Zhi-yong Xiao Xiao-yan Zheng Li-ying Liu Zheng Yu Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis BMJ Open |
| title | Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis |
| title_full | Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis |
| title_fullStr | Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis |
| title_full_unstemmed | Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis |
| title_short | Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and network meta-analysis |
| title_sort | effect of non pharmacological interventions for overweight obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes a protocol for a systematic review and network meta analysis |
| url | https://bmjopen.bmj.com/content/12/6/e059090.full |
| work_keys_str_mv | AT juanli effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT jieyang effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT fanrongliang effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT junzhou effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT guixingxu effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT hanyang effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT yanqunxiao effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT jiajialiu effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT zhiyongxiao effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT xiaoyanzheng effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT liyingliu effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis AT zhengyu effectofnonpharmacologicalinterventionsforoverweightobesewomenwithpolycysticovarysyndromeonovulationandpregnancyoutcomesaprotocolforasystematicreviewandnetworkmetaanalysis |