Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work. All the new compounds’ structures were elucidated by elemental analyses, IR, 1H NMR, 13...

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Main Authors: Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim
Format: Article
Language:English
Published: Sciendo 2020-12-01
Series:Acta Pharmaceutica
Subjects:
1
3
4-thiadiazole
anticancer activity
aromatase inhibitory activity
mtt assay
Online Access:https://doi.org/10.2478/acph-2020-0034
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