Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice

Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice

Abstract Background Apolipoprotein E4 (ApoE4) is associated with an increased risk of Alzheimer’s disease (AD), depression, and anxiety, which were reported to improve after the administration of metformin. However, sex influence on the effect of ApoE4 and metformin on cognition and mental health is...

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Bibliographic Details
Main Authors: Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biology of Sex Differences
Subjects:
Apolipoprotein E4
Metformin
Sex difference
Cognition
Anxiety
Depression
Online Access:https://doi.org/10.1186/s13293-025-00684-w
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