Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis
Background. Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating dis...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/3378035 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554951126024192 |
|---|---|
| author | Yandan Zhou Min Xu Wei Gong Xiaoming Kang Renzhong Guo Jie Wen Dinggang Zhou Manjing Wang Dazhi Shi Qiancheng Jing |
| author_facet | Yandan Zhou Min Xu Wei Gong Xiaoming Kang Renzhong Guo Jie Wen Dinggang Zhou Manjing Wang Dazhi Shi Qiancheng Jing |
| author_sort | Yandan Zhou |
| collection | DOAJ |
| description | Background. Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating disease severity and predicting efficacy of SLIT in AR patients. Methods. We enrolled 110 moderate-severe persist AR patients (AR group) and 40 healthy controls (HC group). Circulating levels of MRGPRX2 and MMP-12 were measured, and their associations with disease severity were evaluated. All AR patients were assigned to receive sublingual immunotherapy (SLIT), and the efficacy was evaluated, and serum samples were collected at 1 year and 3 years after treatment. The correlations between serum MRGPRX2 and MMP-12 and clinical efficacy were assessed. Results. The serum concentrations of MRGPRX2 and MMP-12 were significantly higher in the AR group than the HC group, and the elevated MMP-12 levels were correlated with VAS and TNSS, and serum MRGPRX2 levels were correlated with VAS. Finally, 100 and 80 patients completed 1-year and 3-year follow-up and were classified into effective and ineffective groups. Serum MRGPRX2 and MMP-12 levels were lower in the effective group than the ineffective group. Although serum MRGPRX2 and MMP-12 levels did not significantly change after 1 year SLIT, serum MMP-12 levels were decreased 3 years post-SLIT than baseline and 1 year post-SLIT levels. Receiver operating characteristic (ROC) showed that serum MMP-12 was a potential biomarker for predicting the efficacy of SLIT. Conclusion. Serum MRGPRX2 and MMP-12 appeared to be promising biological indicators in reflecting disease severity in AR patients. Moreover, circulating MMP-12 might serve as a reliable predictor for clinical responsiveness of SLIT. |
| format | Article |
| id | doaj-art-02838089f3434d908176f98856795538 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-02838089f3434d908176f988567955382025-02-03T05:50:01ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/3378035Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic RhinitisYandan Zhou0Min Xu1Wei Gong2Xiaoming Kang3Renzhong Guo4Jie Wen5Dinggang Zhou6Manjing Wang7Dazhi Shi8Qiancheng Jing9Changsha Aier Eye HospitalDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck SurgeryBackground. Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating disease severity and predicting efficacy of SLIT in AR patients. Methods. We enrolled 110 moderate-severe persist AR patients (AR group) and 40 healthy controls (HC group). Circulating levels of MRGPRX2 and MMP-12 were measured, and their associations with disease severity were evaluated. All AR patients were assigned to receive sublingual immunotherapy (SLIT), and the efficacy was evaluated, and serum samples were collected at 1 year and 3 years after treatment. The correlations between serum MRGPRX2 and MMP-12 and clinical efficacy were assessed. Results. The serum concentrations of MRGPRX2 and MMP-12 were significantly higher in the AR group than the HC group, and the elevated MMP-12 levels were correlated with VAS and TNSS, and serum MRGPRX2 levels were correlated with VAS. Finally, 100 and 80 patients completed 1-year and 3-year follow-up and were classified into effective and ineffective groups. Serum MRGPRX2 and MMP-12 levels were lower in the effective group than the ineffective group. Although serum MRGPRX2 and MMP-12 levels did not significantly change after 1 year SLIT, serum MMP-12 levels were decreased 3 years post-SLIT than baseline and 1 year post-SLIT levels. Receiver operating characteristic (ROC) showed that serum MMP-12 was a potential biomarker for predicting the efficacy of SLIT. Conclusion. Serum MRGPRX2 and MMP-12 appeared to be promising biological indicators in reflecting disease severity in AR patients. Moreover, circulating MMP-12 might serve as a reliable predictor for clinical responsiveness of SLIT.http://dx.doi.org/10.1155/2022/3378035 |
| spellingShingle | Yandan Zhou Min Xu Wei Gong Xiaoming Kang Renzhong Guo Jie Wen Dinggang Zhou Manjing Wang Dazhi Shi Qiancheng Jing Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Mediators of Inflammation |
| title | Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis |
| title_full | Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis |
| title_fullStr | Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis |
| title_full_unstemmed | Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis |
| title_short | Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis |
| title_sort | circulating mmp 12 as potential biomarker in evaluating disease severity and efficacy of sublingual immunotherapy in allergic rhinitis |
| url | http://dx.doi.org/10.1155/2022/3378035 |
| work_keys_str_mv | AT yandanzhou circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT minxu circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT weigong circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT xiaomingkang circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT renzhongguo circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT jiewen circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT dinggangzhou circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT manjingwang circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT dazhishi circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis AT qianchengjing circulatingmmp12aspotentialbiomarkerinevaluatingdiseaseseverityandefficacyofsublingualimmunotherapyinallergicrhinitis |