T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications
In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarize...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/501659 |
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| _version_ | 1832553723819196416 |
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| author | Claudio Fozza Maurizio Longinotti |
| author_facet | Claudio Fozza Maurizio Longinotti |
| author_sort | Claudio Fozza |
| collection | DOAJ |
| description | In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines. We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL. |
| format | Article |
| id | doaj-art-0273cde4652f4b9abc2f3213edaf5945 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-0273cde4652f4b9abc2f3213edaf59452025-02-03T05:53:16ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/501659501659T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic ImplicationsClaudio Fozza0Maurizio Longinotti1Institute of Hematology, University of Sassari, Viale San Pietro 12, 07100 Sassari, ItalyInstitute of Hematology, University of Sassari, Viale San Pietro 12, 07100 Sassari, ItalyIn hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines. We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL.http://dx.doi.org/10.1155/2011/501659 |
| spellingShingle | Claudio Fozza Maurizio Longinotti T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications Advances in Hematology |
| title | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
| title_full | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
| title_fullStr | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
| title_full_unstemmed | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
| title_short | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
| title_sort | t cell traffic jam in hodgkin s lymphoma pathogenetic and therapeutic implications |
| url | http://dx.doi.org/10.1155/2011/501659 |
| work_keys_str_mv | AT claudiofozza tcelltrafficjaminhodgkinslymphomapathogeneticandtherapeuticimplications AT mauriziolonginotti tcelltrafficjaminhodgkinslymphomapathogeneticandtherapeuticimplications |