Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Abstract Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases. However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS). The establishment of a CNS axotomy model (using modified 3D LUHMES cultures) allow...

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Bibliographic Details
Main Authors: Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07326-w
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