Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia
Background: Preeclampsia is a hypertensive disorder of pregnancy that ultimately led to high mortality and morbidity due to its complication HELP (Hemolysis, Elevated Liver Enzymes, and Low Platelet count), syndrome, and its association with elevated liver function tests. The main objective of this...
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ziauddin University
2025-01-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3244 |
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| author | Sadia Chaudhary Hafiza Ateeqa Mubarak Anila Sabir Hina Sadaf Anas Khalil Zahid Mahmood Marium Shoukat Farah Naz Tahir |
| author_facet | Sadia Chaudhary Hafiza Ateeqa Mubarak Anila Sabir Hina Sadaf Anas Khalil Zahid Mahmood Marium Shoukat Farah Naz Tahir |
| author_sort | Sadia Chaudhary |
| collection | DOAJ |
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Background: Preeclampsia is a hypertensive disorder of pregnancy that ultimately led to high mortality and morbidity due to its complication HELP (Hemolysis, Elevated Liver Enzymes, and Low Platelet count), syndrome, and its association with elevated liver function tests. The main objective of this study is to investigate the association between elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) and severe maternal outcomes in women diagnosed with preeclampsia.
Methods: A cross-sectional study was conducted using convenience sampling at the Department of Obstetrics and Gynecology, Central Park Teaching Hospital Lahore Pakistan from April 18, 2024, to August 5, 2024. Group A with severe maternal outcome group eclampsia, HELLP, and group B without severe outcome. Liver function tests (AST, ALT, and ALP) were measured upon diagnosis. Severe maternal outcomes were statistically analyzed using SPSS version 26 applying a paired t-test.
Results: Among 300 women diagnosed with preeclampsia 90(30%) had increased LFTs and severe maternal outcomes were measured in 45 (50%) women with increased LFTs as compared to 30 (14.3%) women with normal LFTs(p=0.001). logistic regression analysis also showed that increased ALT (OR 3.7, 95%CI 2.01-7.02, p<0.001) and AST (OR 4.4, 95%CI 2.4-8.02, P<0.001) were significant predictors of severe maternal outcome while ALP was not associated with severe outcomes (OR 1.2, 95%CI 0.8-2.4, p=0.41).
Conclusion: This study provides new insight into the prognostic values of LFTs, which could increase their prognostic value and improve clinical decision-making and maternal care in preeclampsia.
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| format | Article |
| id | doaj-art-025acda54fd94eed8ebe3ce5e784a6d0 |
| institution | Kabale University |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | ziauddin University |
| record_format | Article |
| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-025acda54fd94eed8ebe3ce5e784a6d02025-01-19T20:18:31Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-01-0114110.36283/ziun-pjmd14-1/018Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with PreeclampsiaSadia Chaudhary0Hafiza Ateeqa Mubarak1Anila Sabir2Hina Sadaf3Anas Khalil4Zahid Mahmood5Marium Shoukat6Farah Naz Tahir7https://orcid.org/0000-0002-0693-9559Rahbar Medical and Dental College Lahore ,Pakistan. Ghurki trust and Teaching Hospital, Lahore, Pakistan.Sharif Medical and Dental College and Hospital, Lahore, Pakistan.Azra Naheed Medical College,Lahore,Pakistan. Wah Medical College, Rawalpindi, Pakistan. Wah Medical College, Rawalpindi, Pakistan. Rahbar Medical and Dental College Lahore Central Park Medical College, Lahore, Pakistan. Background: Preeclampsia is a hypertensive disorder of pregnancy that ultimately led to high mortality and morbidity due to its complication HELP (Hemolysis, Elevated Liver Enzymes, and Low Platelet count), syndrome, and its association with elevated liver function tests. The main objective of this study is to investigate the association between elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) and severe maternal outcomes in women diagnosed with preeclampsia. Methods: A cross-sectional study was conducted using convenience sampling at the Department of Obstetrics and Gynecology, Central Park Teaching Hospital Lahore Pakistan from April 18, 2024, to August 5, 2024. Group A with severe maternal outcome group eclampsia, HELLP, and group B without severe outcome. Liver function tests (AST, ALT, and ALP) were measured upon diagnosis. Severe maternal outcomes were statistically analyzed using SPSS version 26 applying a paired t-test. Results: Among 300 women diagnosed with preeclampsia 90(30%) had increased LFTs and severe maternal outcomes were measured in 45 (50%) women with increased LFTs as compared to 30 (14.3%) women with normal LFTs(p=0.001). logistic regression analysis also showed that increased ALT (OR 3.7, 95%CI 2.01-7.02, p<0.001) and AST (OR 4.4, 95%CI 2.4-8.02, P<0.001) were significant predictors of severe maternal outcome while ALP was not associated with severe outcomes (OR 1.2, 95%CI 0.8-2.4, p=0.41). Conclusion: This study provides new insight into the prognostic values of LFTs, which could increase their prognostic value and improve clinical decision-making and maternal care in preeclampsia. https://ojs.zu.edu.pk/pjmd/article/view/3244PreeclampsiaLiver Function TestMaternal Mortality |
| spellingShingle | Sadia Chaudhary Hafiza Ateeqa Mubarak Anila Sabir Hina Sadaf Anas Khalil Zahid Mahmood Marium Shoukat Farah Naz Tahir Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia Pakistan Journal of Medicine and Dentistry Preeclampsia Liver Function Test Maternal Mortality |
| title | Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia |
| title_full | Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia |
| title_fullStr | Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia |
| title_full_unstemmed | Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia |
| title_short | Elevated Liver Function Tests as Predictors of Severe Maternal Outcomes in Women with Preeclampsia |
| title_sort | elevated liver function tests as predictors of severe maternal outcomes in women with preeclampsia |
| topic | Preeclampsia Liver Function Test Maternal Mortality |
| url | https://ojs.zu.edu.pk/pjmd/article/view/3244 |
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