Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia
Background: Schizophrenia causes significant neurocognitive impairment. Treatment with antipsychotics leads to improvement in psychopathology and neurocognitive functions. Aim: To see comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia. M...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-10-01
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| Series: | Indian Journal of Psychiatry |
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| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_303_23 |
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| author | Sanya Sharma Ajeet Sidana Shivangi Mehta Manoj Kumar Bajaj |
| author_facet | Sanya Sharma Ajeet Sidana Shivangi Mehta Manoj Kumar Bajaj |
| author_sort | Sanya Sharma |
| collection | DOAJ |
| description | Background:
Schizophrenia causes significant neurocognitive impairment. Treatment with antipsychotics leads to improvement in psychopathology and neurocognitive functions.
Aim:
To see comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia.
Materials and Methods:
This was a comparative, prospective, and interventional study. Patients with schizophrenia as per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), were assessed on Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), and neuropsychological tests at baseline. Patients were randomly assigned to aripiprazole (10–30 mg per day, orally) and olanzapine (5–20 mg per day, orally) groups on the basis of computer-generated random table number. Patients were reassessed at 10 weeks.
Results:
A total of 40 patients completed the study duration of 10 weeks. At baseline, the majority of patients showed significant impairment in one or more domains of neurocognition. Both aripiprazole and olanzapine led to improvement in psychiatric symptoms as well as neurocognitive profile. Aripiprazole treatment leads to significant improvement in mental speed as compared to olanzapine. A highly significant decrease in the value of the Stroop effect indicates improvement (P = 0.000**) with aripiprazole and visual–spatial constructive ability (P < 0.001). The olanzapine group showed highly significant improvement in performance of category fluency (P < 0.01) and verbal fluency (P < 0.01).
Conclusion:
The study concludes that aripiprazole and olanzapine have strong potential to improve specific domains of neurocognitive profile. |
| format | Article |
| id | doaj-art-025726c4b7c74a90b9287906dae7ad99 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-025726c4b7c74a90b9287906dae7ad992025-01-26T08:54:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-10-0165101044105110.4103/indianjpsychiatry.indianjpsychiatry_303_23Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophreniaSanya SharmaAjeet SidanaShivangi MehtaManoj Kumar BajajBackground: Schizophrenia causes significant neurocognitive impairment. Treatment with antipsychotics leads to improvement in psychopathology and neurocognitive functions. Aim: To see comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia. Materials and Methods: This was a comparative, prospective, and interventional study. Patients with schizophrenia as per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), were assessed on Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), and neuropsychological tests at baseline. Patients were randomly assigned to aripiprazole (10–30 mg per day, orally) and olanzapine (5–20 mg per day, orally) groups on the basis of computer-generated random table number. Patients were reassessed at 10 weeks. Results: A total of 40 patients completed the study duration of 10 weeks. At baseline, the majority of patients showed significant impairment in one or more domains of neurocognition. Both aripiprazole and olanzapine led to improvement in psychiatric symptoms as well as neurocognitive profile. Aripiprazole treatment leads to significant improvement in mental speed as compared to olanzapine. A highly significant decrease in the value of the Stroop effect indicates improvement (P = 0.000**) with aripiprazole and visual–spatial constructive ability (P < 0.001). The olanzapine group showed highly significant improvement in performance of category fluency (P < 0.01) and verbal fluency (P < 0.01). Conclusion: The study concludes that aripiprazole and olanzapine have strong potential to improve specific domains of neurocognitive profile.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_303_23aripiprazoleneurocognitive functionsolanzapineschizophrenia |
| spellingShingle | Sanya Sharma Ajeet Sidana Shivangi Mehta Manoj Kumar Bajaj Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia Indian Journal of Psychiatry aripiprazole neurocognitive functions olanzapine schizophrenia |
| title | Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| title_full | Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| title_fullStr | Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| title_full_unstemmed | Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| title_short | Comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| title_sort | comparative effectiveness of aripiprazole and olanzapine on neurocognitive profile of patients with schizophrenia |
| topic | aripiprazole neurocognitive functions olanzapine schizophrenia |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_303_23 |
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