Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules

Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules

Abstract Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are a promising class of intracellular delivery vehicles that can release macromolecular modalities deployed in a wide range of therapeutic treatments. However, the molecular grammar governing intracellular...

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Bibliographic Details
Main Authors: Yue Sun, Xi Wu, Jianguo Li, Milad Radiom, Raffaele Mezzenga, Chandra Shekhar Verma, Jing Yu, Ali Miserez
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54463-z
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