Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats
Lead (Pb) is a highly toxic heavy metal that can cause harm even at extremely low concentrations and damage various organs, including those of reproduction. Medical herbs like Nigella sativa include antioxidants that have been shown to enhance spermatogenesis and male fertility. This research aimed...
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Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
2025-03-01
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| Series: | Journal of Advanced Biotechnology and Experimental Therapeutics |
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| Online Access: | https://www.bsmiab.org/jabet/?mno=217134 |
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| author | Afrina Mustari Mahabub Alam Samia Rashid A.G.M.Sofi Uddin Mahamud Mohammad Alam Miah Emdadul Hauqe Chowdhury |
| author_facet | Afrina Mustari Mahabub Alam Samia Rashid A.G.M.Sofi Uddin Mahamud Mohammad Alam Miah Emdadul Hauqe Chowdhury |
| author_sort | Afrina Mustari |
| collection | DOAJ |
| description | Lead (Pb) is a highly toxic heavy metal that can cause harm even at extremely low concentrations and damage various organs, including those of reproduction. Medical herbs like Nigella sativa include antioxidants that have been shown to enhance spermatogenesis and male fertility. This research aimed to investigate the gonadal health benefits of Nigella sativa seed oil (NSO) as an antidote in male rats exposed to chronic Pb toxicity. Forty rats were divided into four groups: a control group, a group exposed to Pb acetate (75 mg/kg body weight), a group given NSO (1ml/kg feed), and a group exposed to Pb acetate (75 mg/kg body weight) along with NSO (1ml/kg feed). Pb was administered through water, while NSO with fed for 16 weeks. Rats were euthanized, blood was obtained, and serum was prepared to perform hormonal study. Sperm concentration and motility along with testis weight and diameter were measured. The testes were collected for histology. The findings indicated a significant drop in serum concentrations of testosterone and thyroxin (T4) in Pb-exposed rats, whereas NSO demonstrated a remarkable ability to restore these hormone levels. Moreover, Pb exposure led to a notable reduction in sperm motility, sperm concentration, testis weight, and testis diameter, accompanied by seminiferous tubule degeneration. However, the administration of NSO effectively counteracted the adverse effects induced by chronic Pb exposure in rats. Together, these findings revealed the gonadoprotective effects of NSO against lead toxicity, suggesting its preventive as well as therapeutic potential in preserving the testicular function of rats exposed to chronic Pb toxicity. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 44-54] |
| format | Article |
| id | doaj-art-0249ca3549fb4015b5e98f5db90ed8ae |
| institution | Kabale University |
| issn | 2616-4760 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology |
| record_format | Article |
| series | Journal of Advanced Biotechnology and Experimental Therapeutics |
| spelling | doaj-art-0249ca3549fb4015b5e98f5db90ed8ae2025-01-30T13:01:08ZengBangladesh Society for Microbiology, Immunology, and Advanced BiotechnologyJournal of Advanced Biotechnology and Experimental Therapeutics2616-47602025-03-0181445410.5455/jabet.2025.04217134Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar ratsAfrina Mustari0Mahabub Alam1Samia Rashid2A.G.M.Sofi Uddin Mahamud3Mohammad Alam Miah4Emdadul Hauqe Chowdhury5Department of Physiology, Faculty of Veterinary science Department of Physiology Bangladesh Agricultural University Mymensingh-2202 Department of Physiology Bangladesh Agricultural University Mymensingh-2202 ABEx Bio-Research Center, East Azampur, Dhaka-1230, Bangladesh Department of Physiology Bangladesh Agricultural University Mymensingh-2202 Department of Pathology Bangladesh Agricultural University Mymensingh-2202Lead (Pb) is a highly toxic heavy metal that can cause harm even at extremely low concentrations and damage various organs, including those of reproduction. Medical herbs like Nigella sativa include antioxidants that have been shown to enhance spermatogenesis and male fertility. This research aimed to investigate the gonadal health benefits of Nigella sativa seed oil (NSO) as an antidote in male rats exposed to chronic Pb toxicity. Forty rats were divided into four groups: a control group, a group exposed to Pb acetate (75 mg/kg body weight), a group given NSO (1ml/kg feed), and a group exposed to Pb acetate (75 mg/kg body weight) along with NSO (1ml/kg feed). Pb was administered through water, while NSO with fed for 16 weeks. Rats were euthanized, blood was obtained, and serum was prepared to perform hormonal study. Sperm concentration and motility along with testis weight and diameter were measured. The testes were collected for histology. The findings indicated a significant drop in serum concentrations of testosterone and thyroxin (T4) in Pb-exposed rats, whereas NSO demonstrated a remarkable ability to restore these hormone levels. Moreover, Pb exposure led to a notable reduction in sperm motility, sperm concentration, testis weight, and testis diameter, accompanied by seminiferous tubule degeneration. However, the administration of NSO effectively counteracted the adverse effects induced by chronic Pb exposure in rats. Together, these findings revealed the gonadoprotective effects of NSO against lead toxicity, suggesting its preventive as well as therapeutic potential in preserving the testicular function of rats exposed to chronic Pb toxicity. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 44-54]https://www.bsmiab.org/jabet/?mno=217134nigella sativa oilleadchronicsperm and testis |
| spellingShingle | Afrina Mustari Mahabub Alam Samia Rashid A.G.M.Sofi Uddin Mahamud Mohammad Alam Miah Emdadul Hauqe Chowdhury Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats Journal of Advanced Biotechnology and Experimental Therapeutics nigella sativa oil lead chronic sperm and testis |
| title | Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats |
| title_full | Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats |
| title_fullStr | Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats |
| title_full_unstemmed | Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats |
| title_short | Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats |
| title_sort | gonadal health benefits of black cumin nigella sativa seed oil on chronic lead exposed male wistar rats |
| topic | nigella sativa oil lead chronic sperm and testis |
| url | https://www.bsmiab.org/jabet/?mno=217134 |
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