Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/1253245 |
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| author | Joseph Bouskila Vanessa Harrar Pasha Javadi Amy Beierschmitt Roberta Palmour Christian Casanova Jean-François Bouchard Maurice Ptito |
| author_facet | Joseph Bouskila Vanessa Harrar Pasha Javadi Amy Beierschmitt Roberta Palmour Christian Casanova Jean-François Bouchard Maurice Ptito |
| author_sort | Joseph Bouskila |
| collection | DOAJ |
| description | The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function. |
| format | Article |
| id | doaj-art-024580094f244d30a40abe040e38e732 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-024580094f244d30a40abe040e38e7322025-02-03T06:01:15ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/12532451253245Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet MonkeysJoseph Bouskila0Vanessa Harrar1Pasha Javadi2Amy Beierschmitt3Roberta Palmour4Christian Casanova5Jean-François Bouchard6Maurice Ptito7School of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaSchool of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaSchool of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaSt. Kitts Behavioral Science Foundation, Basseterre, Saint Kitts and NevisSt. Kitts Behavioral Science Foundation, Basseterre, Saint Kitts and NevisSchool of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaSchool of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaSchool of Optometry, University of Montreal, Montreal, QC, H3T 1P1, CanadaThe expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function.http://dx.doi.org/10.1155/2016/1253245 |
| spellingShingle | Joseph Bouskila Vanessa Harrar Pasha Javadi Amy Beierschmitt Roberta Palmour Christian Casanova Jean-François Bouchard Maurice Ptito Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys Neural Plasticity |
| title | Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys |
| title_full | Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys |
| title_fullStr | Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys |
| title_full_unstemmed | Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys |
| title_short | Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys |
| title_sort | cannabinoid receptors cb1 and cb2 modulate the electroretinographic waves in vervet monkeys |
| url | http://dx.doi.org/10.1155/2016/1253245 |
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