Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions
MR has become a reliable and noninvasive method of hepatic iron quantification. Currently, most of the hepatic iron quantification is performed on 1.5 T MR, and the biopsy measurements have been paired with R2 and R2* values for 1.5 T MR. As the use of 3 T MR scanners is steadily increasing in clini...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/628150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560990040883200 |
|---|---|
| author | Muhammad Anwar John Wood Deepa Manwani Benjamin Taragin Suzette O. Oyeku Qi Peng |
| author_facet | Muhammad Anwar John Wood Deepa Manwani Benjamin Taragin Suzette O. Oyeku Qi Peng |
| author_sort | Muhammad Anwar |
| collection | DOAJ |
| description | MR has become a reliable and noninvasive method of hepatic iron quantification. Currently, most of the hepatic iron quantification is performed on 1.5 T MR, and the biopsy measurements have been paired with R2 and R2* values for 1.5 T MR. As the use of 3 T MR scanners is steadily increasing in clinical practice, it has become important to evaluate the practicality of calculating iron burden at 3 T MR. Hepatic iron quantification on 3 T MR requires a better understanding of the process and more stringent technical considerations. The purpose of this work is to focus on the technical challenges in establishing a relationship between T2* values at 1.5 T MR and 3 T MR for hepatic iron concentration (HIC) and to develop an appropriately optimized MR protocol for the evaluation of T2* values in the liver at 3 T magnetic field strength. We studied 22 sickle cell patients using multiecho fast gradient-echo sequence (MFGRE) 3 T MR and compared the results with serum ferritin and liver biopsy results. Our study showed that the quantification of hepatic iron on 3 T MRI in sickle cell disease patients correlates well with clinical blood test results and biopsy results. 3 T MR liver iron quantification based on MFGRE can be used for hepatic iron quantification in transfused patients. |
| format | Article |
| id | doaj-art-021ec8992ad44d29be1ca25eff6dbd76 |
| institution | Kabale University |
| issn | 2090-1941 2090-195X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj-art-021ec8992ad44d29be1ca25eff6dbd762025-02-03T01:26:13ZengWileyRadiology Research and Practice2090-19412090-195X2013-01-01201310.1155/2013/628150628150Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and SolutionsMuhammad Anwar0John Wood1Deepa Manwani2Benjamin Taragin3Suzette O. Oyeku4Qi Peng5Department of Pediatric Radiology, Children’s Hospital at Montefiore, Bronx, NY, USADepartment of Pediatric Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, USADepartment of Pediatrics, Division of Pediatric Hematology/Oncology, Children’s Hospital at Montefiore, Bronx, NY, USADepartment of Pediatric Radiology, Children’s Hospital at Montefiore, Bronx, NY, USADepartment of Pediatrics, Division of General Pediatrics, Children’s Hospital at Montefiore, Bronx, NY, USADepartment of Pediatric Radiology, Children’s Hospital at Montefiore, Bronx, NY, USAMR has become a reliable and noninvasive method of hepatic iron quantification. Currently, most of the hepatic iron quantification is performed on 1.5 T MR, and the biopsy measurements have been paired with R2 and R2* values for 1.5 T MR. As the use of 3 T MR scanners is steadily increasing in clinical practice, it has become important to evaluate the practicality of calculating iron burden at 3 T MR. Hepatic iron quantification on 3 T MR requires a better understanding of the process and more stringent technical considerations. The purpose of this work is to focus on the technical challenges in establishing a relationship between T2* values at 1.5 T MR and 3 T MR for hepatic iron concentration (HIC) and to develop an appropriately optimized MR protocol for the evaluation of T2* values in the liver at 3 T magnetic field strength. We studied 22 sickle cell patients using multiecho fast gradient-echo sequence (MFGRE) 3 T MR and compared the results with serum ferritin and liver biopsy results. Our study showed that the quantification of hepatic iron on 3 T MRI in sickle cell disease patients correlates well with clinical blood test results and biopsy results. 3 T MR liver iron quantification based on MFGRE can be used for hepatic iron quantification in transfused patients.http://dx.doi.org/10.1155/2013/628150 |
| spellingShingle | Muhammad Anwar John Wood Deepa Manwani Benjamin Taragin Suzette O. Oyeku Qi Peng Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions Radiology Research and Practice |
| title | Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions |
| title_full | Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions |
| title_fullStr | Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions |
| title_full_unstemmed | Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions |
| title_short | Hepatic Iron Quantification on 3 Tesla (3 T) Magnetic Resonance (MR): Technical Challenges and Solutions |
| title_sort | hepatic iron quantification on 3 tesla 3 t magnetic resonance mr technical challenges and solutions |
| url | http://dx.doi.org/10.1155/2013/628150 |
| work_keys_str_mv | AT muhammadanwar hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions AT johnwood hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions AT deepamanwani hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions AT benjamintaragin hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions AT suzetteooyeku hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions AT qipeng hepaticironquantificationon3tesla3tmagneticresonancemrtechnicalchallengesandsolutions |