Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L
Serum ferritin rises in the anemia of chronic inflammation reflecting increased iron storage and other changes mediated by inflammation. When iron deficiency coexists, the ferritin may not always decline into the subnormal range. We describe the rare interaction of iron deficiency with the extreme h...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2011/184748 |
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| author | Sheetal Patel Seyed Monemian Ayesha Khalid Harvey Dosik |
| author_facet | Sheetal Patel Seyed Monemian Ayesha Khalid Harvey Dosik |
| author_sort | Sheetal Patel |
| collection | DOAJ |
| description | Serum ferritin rises in the anemia of chronic inflammation reflecting increased iron storage and other changes mediated by inflammation. When iron deficiency coexists, the ferritin may not always decline into the subnormal range. We describe the rare interaction of iron deficiency with the extreme hyperferritinemia characteristic of adult onset Still's disease. The combination has clinical relevance and allows deductions about the presence of serum ferritin at 26,387 μg/L despite obvious iron depletion. The diagnosis of iron deficiency anemia was delayed and became fully obvious when her Still's disease remitted and serum ferritin decreased to 6.5 μg/L. The coexistence of iron deficiency should be considered when evaluating a patient with anemia of chronic inflammation even when the ferritin level is elevated several hundredfold. Further insights on ferritin metabolism in Still's disease are suggested by the likelihood that the patient's massive hyperferritinemia in the acute phase of Still's disease was almost entirely of the iron-free apoferritin form. |
| format | Article |
| id | doaj-art-01f9b2ec70c9487395ae0bf0e3286534 |
| institution | Kabale University |
| issn | 2090-1267 2090-1275 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-01f9b2ec70c9487395ae0bf0e32865342025-02-03T06:01:15ZengWileyAnemia2090-12672090-12752011-01-01201110.1155/2011/184748184748Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/LSheetal Patel0Seyed Monemian1Ayesha Khalid2Harvey Dosik3Department of Internal Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USADivision of Hematology-Oncology, Department of Internal Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USADepartment of Internal Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USADivision of Hematology, Department of Internal Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USASerum ferritin rises in the anemia of chronic inflammation reflecting increased iron storage and other changes mediated by inflammation. When iron deficiency coexists, the ferritin may not always decline into the subnormal range. We describe the rare interaction of iron deficiency with the extreme hyperferritinemia characteristic of adult onset Still's disease. The combination has clinical relevance and allows deductions about the presence of serum ferritin at 26,387 μg/L despite obvious iron depletion. The diagnosis of iron deficiency anemia was delayed and became fully obvious when her Still's disease remitted and serum ferritin decreased to 6.5 μg/L. The coexistence of iron deficiency should be considered when evaluating a patient with anemia of chronic inflammation even when the ferritin level is elevated several hundredfold. Further insights on ferritin metabolism in Still's disease are suggested by the likelihood that the patient's massive hyperferritinemia in the acute phase of Still's disease was almost entirely of the iron-free apoferritin form.http://dx.doi.org/10.1155/2011/184748 |
| spellingShingle | Sheetal Patel Seyed Monemian Ayesha Khalid Harvey Dosik Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L Anemia |
| title | Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L |
| title_full | Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L |
| title_fullStr | Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L |
| title_full_unstemmed | Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L |
| title_short | Iron Deficiency Anemia in Adult Onset Still's Disease with a Serum Ferritin of 26,387 μg/L |
| title_sort | iron deficiency anemia in adult onset still s disease with a serum ferritin of 26 387 μg l |
| url | http://dx.doi.org/10.1155/2011/184748 |
| work_keys_str_mv | AT sheetalpatel irondeficiencyanemiainadultonsetstillsdiseasewithaserumferritinof26387mgl AT seyedmonemian irondeficiencyanemiainadultonsetstillsdiseasewithaserumferritinof26387mgl AT ayeshakhalid irondeficiencyanemiainadultonsetstillsdiseasewithaserumferritinof26387mgl AT harveydosik irondeficiencyanemiainadultonsetstillsdiseasewithaserumferritinof26387mgl |