Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Abstract Background/aims The molecular mechanisms driving nonalcoholic steatohepatitis (NASH) progression are poorly understood. This research examines the involvement of chaperone‐mediated autophagy (CMA) in NASH progression. Methods Hepatic CMA activity was analysed in NASH mice and patients. Lyso...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shuoyi Ma, Erzhuo Xia, Miao Zhang, Yinan Hu, Siyuan Tian, Xiaohong Zheng, Bo Li, Gang Ma, Rui Su, Keshuai Sun, Qingling Fan, Fangfang Yang, Guanya Guo, Changcun Guo, Yulong Shang, Xinmin Zhou, Xia Zhou, Jingbo Wang, Ying Han
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Series:	Clinical and Translational Medicine
Subjects:	chaperone‐mediated autophagy cholesterol endoplasmic reticulum stress FOXM1 nonalcoholic steatohepatitis
Online Access:	https://doi.org/10.1002/ctm2.70202
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clinical and pathogenetic differences of the course of flow nonalcoholic steatohepatitis in obese patients with and without hypertension
by: O.S. Khukhlina, et al.
Published: (2013-08-01)

The effectiveness of the integrated use of gepadif, ezetrol and fosinopril in the nonalcoholic steatohepatitis in patients with hypertension stage II
by: O. S. Khukhlina, et al.
Published: (2017-03-01)

CAT and CXCL8 are crucial cofactors for the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma, the immune infiltration and prognosis of hepatocellular carcinoma
by: Liang Yang, et al.
Published: (2025-03-01)

Ductular reaction in alcoholic steatohepatitis, nonalcoholic steatohepatitis and hepatitis C virus infection (immunohistochemical study)
by: O. M. Gavrilyuk
Published: (2014-04-01)

The impact of the ursodeoxycholic acid as monotherapy and in the combination with the lactulose on the biochemical blood tests values of the nonalcoholic steatohepatitis patients
by: I. V. Mayev, et al.
Published: (2013-03-01)

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis
by: Peiyuan Gu, et al.
Published: (2025-03-01)

Catechins promoted Enterococcus faecalis to alleviate related indices of nonalcoholic steatohepatitis mice induced by high-fat diet
by: Ying Zhang, et al.
Published: (2025-07-01)

Nonobese mice with nonalcoholic steatohepatitis fed on a choline‐deficient, l‐amino acid‐defined, high‐fat diet exhibit alterations in signaling pathways
by: Noriko Suzuki‐Kemuriyama, et al.
Published: (2021-11-01)

Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis in vivo and in vitro
by: Keyu Chen, et al.
Published: (2025-06-01)

EFFECT OF S-ADENOSYLMETHIONINE ON HEPATIC AND METABOLIC DISORDERS IN GUINEA PIGS WITH NONALCOHOLIC STEATOHEPATITIS
by: İlknur Bingül, et al.
Published: (2025-01-01)

Correction: Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis in vivo and in vitro
by: Keyu Chen, et al.
Published: (2025-08-01)

PREVALENCE AND RISK FACTORS ASSOCIATED WITH NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH RHEUMATOID ARTHRITIS ON HYDROXYCHLOROQUINE: A POPULATION-BASED STUDY
by: Antoine BOUSTANY, et al.
Published: (2025-04-01)

Farnesoid X receptor (FXR) as a potential therapeutic target in nonalcoholic fatty liver disease and associated syndromes
by: Apollinariya V. Bogolyubova, et al.
Published: (2017-12-01)

Deposition features of heterovalent iron (Fe2 + and Fe3 +) in the liver in alcoholic and nonalcoholic steatohepatitis
by: V. A. Tumanskiy, et al.
Published: (2015-12-01)

Diagnostics of progression of liver fibrosis in patients with non-alcoholic steatohepatitis combined with obesity and chronic calculous cholecystitis.
by: A. Yu. Filippova
Published: (2020-04-01)

Prediction of course and progression of nonalcoholic fatty liver disease in patients with obesity and pathology of the biliary tract with the help of mathematical modeling.
by: A. Yu. Filippova, et al.
Published: (2017-12-01)

Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?
by: Ekaterina E. Mishina, et al.
Published: (2017-12-01)

Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis
by: Jyothi Padiadpu, et al.
Published: (2023-10-01)

Features of the connective tissue metabolism, the content of adipokines and cytokeratin-18 in patients with non-alcoholic steatohepatitis combined with osteoarthritis and obesity
by: O. S. Khukhlina, et al.
Published: (2019-07-01)

Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats
by: Yue Wang, et al.
Published: (2024-11-01)

Possibilities of correction of lipid-phospholipid disorders in patients with non-alcoholic steatohepatitis against obesity and pathology of the biliary tract.
by: A. Yu. Filippova
Published: (2019-11-01)

Research progress on FOXM1 in ovarian cancer diagnosis and therapeutics
by: Xiao-Qing Tan, et al.
Published: (2025-06-01)

Pin1–FOXM1 inhibitors: a potential therapeutic for metastatic melanoma?
by: Peter LJ de Keizer
Published: (2016-09-01)

Features of Glucose Homeostasis and Blood Lipid Spectrum in Patients with Nonalcoholic Fatty Liver Dis ease Depending on the Obesity Degree
by: Korniichuk I., et al.
Published: (2019-04-01)

FOXM1 boosts glycolysis by upregulating SQLE to inhibit anoikis in breast cancer cells
by: Mei Xu, et al.
Published: (2025-05-01)

MiR-378a-3p and miR-181b-5p as nonalcoholic steatohepatitis non-invasive diagnostic biomarkers and their correlations with liver fibrosis
by: T. I. Ahmed, et al.
Published: (2024-08-01)

Non-alcoholic fatty liver disease – a rapidly growing indication for liver transplantation in the modern world
by: I. M. Iljinsky, et al.
Published: (2019-10-01)

The efficiency of metabolic impact of S-adenosylmethionine and meldonium on parameters of lipid profile and insulin resistance during comorbid course of nonalcocholic steatohepatitis, obesity and chronic kidney disease stage І-ІІ
by: O. S. Khukhlina, et al.
Published: (2018-02-01)

Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content
by: Haoxiang Zhu, et al.
Published: (2025-01-01)

SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells
by: Weiwei Tao, et al.
Published: (2020-10-01)

Expression of FOXM1 and PLK1 in Colorectal Cancer and Their Relationship with Clinicopathological Features and Prognosis
by: Xue HAN, et al.
Published: (2025-07-01)

Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis
by: Wei Jiang, et al.
Published: (2025-02-01)

Naringenin attenuates early hepatocarcinogenesis induced by a MASH model
by: Linda Vanessa Márquez-Quiroga, et al.
Published: (2025-07-01)

Identification of immune and major depressive disorder-related diagnostic markers for early nonalcoholic fatty liver disease by WGCNA and machine learning
by: Yuyun Jia, et al.
Published: (2025-06-01)

Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis
by: Feixiang Wu, et al.
Published: (2025-07-01)

Global, regional, and national burden of NASH related liver cancer in adults aged 45 and above: an analysis from the GBD 2021 and forecast to 2050
by: Jianing Shi, et al.
Published: (2025-08-01)

FOXM1 could serve as a bridge mediating prognosis and immunity for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing
by: Jianhua Zhou, et al.
Published: (2025-04-01)

Gaps in MASLD/MASH Education: A Quantitative and Qualitative Survey with Leaders of US Graduate Medical Education Programs
by: Allen AM, et al.
Published: (2025-05-01)

Association of insulin resistance and non-alcoholic fatty liver disease
by: Ekaterina E. Mishina, et al.
Published: (2021-01-01)

Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development
by: Haijun Zhang, et al.
Published: (2025-01-01)