Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time
Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise. P...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4851935 |
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| author | Marius Schild Gerrit Eichner Thomas Beiter Martina Zügel Ilke Krumholz-Wagner Jens Hudemann Christian Pilat Karsten Krüger Andreas M. Niess Jürgen M. Steinacker Frank C. Mooren |
| author_facet | Marius Schild Gerrit Eichner Thomas Beiter Martina Zügel Ilke Krumholz-Wagner Jens Hudemann Christian Pilat Karsten Krüger Andreas M. Niess Jürgen M. Steinacker Frank C. Mooren |
| author_sort | Marius Schild |
| collection | DOAJ |
| description | Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring. |
| format | Article |
| id | doaj-art-01ee25f7f370402280c1b1e6fb68f149 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01ee25f7f370402280c1b1e6fb68f1492025-02-03T01:24:32ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/48519354851935Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over TimeMarius Schild0Gerrit Eichner1Thomas Beiter2Martina Zügel3Ilke Krumholz-Wagner4Jens Hudemann5Christian Pilat6Karsten Krüger7Andreas M. Niess8Jürgen M. Steinacker9Frank C. Mooren10Department of Sports Medicine, Justus-Liebig University Giessen, Kugelberg 62, 35394 Giessen, GermanyMathematical Institute, Justus-Liebig University Giessen, Arndtstraße 2, 35392 Giessen, GermanyDepartment of Sports Medicine, University Hospital of Tuebingen, Hoppe-Seyler-Straße 6, 72076 Tuebingen, GermanyDivision of Sport and Rehabilitation Medicine, University Hospital Ulm, Parkstraße 11, 89075 Ulm, GermanyDepartment of Sports Medicine, Justus-Liebig University Giessen, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, University Hospital of Tuebingen, Hoppe-Seyler-Straße 6, 72076 Tuebingen, GermanyDepartment of Sports Medicine, Justus-Liebig University Giessen, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, Justus-Liebig University Giessen, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, University Hospital of Tuebingen, Hoppe-Seyler-Straße 6, 72076 Tuebingen, GermanyDivision of Sport and Rehabilitation Medicine, University Hospital Ulm, Parkstraße 11, 89075 Ulm, GermanyDepartment of Sports Medicine, Justus-Liebig University Giessen, Kugelberg 62, 35394 Giessen, GermanyAcute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.http://dx.doi.org/10.1155/2016/4851935 |
| spellingShingle | Marius Schild Gerrit Eichner Thomas Beiter Martina Zügel Ilke Krumholz-Wagner Jens Hudemann Christian Pilat Karsten Krüger Andreas M. Niess Jürgen M. Steinacker Frank C. Mooren Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time Mediators of Inflammation |
| title | Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time |
| title_full | Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time |
| title_fullStr | Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time |
| title_full_unstemmed | Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time |
| title_short | Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time |
| title_sort | effects of acute endurance exercise on plasma protein profiles of endurance trained and untrained individuals over time |
| url | http://dx.doi.org/10.1155/2016/4851935 |
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