Adaptive response and enlargement of dynamic range
Many membrane channels and receptors exhibit adaptive, or desensitized,response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation.Adaptive response is thought to be related to various cellular functionssuch as homeostasis and enlargement of dynamic rang...
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AIMS Press
2011-03-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.515 |
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| author | Tamar Friedlander Naama Brenner |
| author_facet | Tamar Friedlander Naama Brenner |
| author_sort | Tamar Friedlander |
| collection | DOAJ |
| description | Many membrane channels and receptors exhibit adaptive, or desensitized,response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation.Adaptive response is thought to be related to various cellular functionssuch as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modelingframework.We show that any particular type of adaptive response is neither sufficient nor necessary for adaptiveenlargement of dynamic range. In particular a precise adaptive response, where system activity is maintainedat a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in systemoutput. A general mechanism for input dynamic range enlargement can come about from the activity-dependentmodulation of protein responsiveness by multiple biochemical modification, regardless of the type of adaptiveresponse it induces. Therefore hierarchical biochemical processes such as methylation and phosphorylationare natural candidates to induce this property in signaling systems. |
| format | Article |
| id | doaj-art-01eb8889848640b5ab4507ffd3c08456 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-01eb8889848640b5ab4507ffd3c084562025-01-24T02:01:39ZengAIMS PressMathematical Biosciences and Engineering1551-00182011-03-018251552810.3934/mbe.2011.8.515Adaptive response and enlargement of dynamic rangeTamar Friedlander0Naama Brenner1Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100Many membrane channels and receptors exhibit adaptive, or desensitized,response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation.Adaptive response is thought to be related to various cellular functionssuch as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modelingframework.We show that any particular type of adaptive response is neither sufficient nor necessary for adaptiveenlargement of dynamic range. In particular a precise adaptive response, where system activity is maintainedat a constant level at steady state, does not ensure a large dynamic range neither in input signal nor in systemoutput. A general mechanism for input dynamic range enlargement can come about from the activity-dependentmodulation of protein responsiveness by multiple biochemical modification, regardless of the type of adaptiveresponse it induces. Therefore hierarchical biochemical processes such as methylation and phosphorylationare natural candidates to induce this property in signaling systems.https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.515feedbacksignal processingbiological networksdynamic rangeadaptive responseintegral control. |
| spellingShingle | Tamar Friedlander Naama Brenner Adaptive response and enlargement of dynamic range Mathematical Biosciences and Engineering feedback signal processing biological networks dynamic range adaptive response integral control. |
| title | Adaptive response and enlargement of dynamic range |
| title_full | Adaptive response and enlargement of dynamic range |
| title_fullStr | Adaptive response and enlargement of dynamic range |
| title_full_unstemmed | Adaptive response and enlargement of dynamic range |
| title_short | Adaptive response and enlargement of dynamic range |
| title_sort | adaptive response and enlargement of dynamic range |
| topic | feedback signal processing biological networks dynamic range adaptive response integral control. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.515 |
| work_keys_str_mv | AT tamarfriedlander adaptiveresponseandenlargementofdynamicrange AT naamabrenner adaptiveresponseandenlargementofdynamicrange |