Anti-tumor potential of Harmine and its derivatives: recent trends and advancements
Abstract Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side effects, especially neurotoxicity, be...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01893-w |
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| _version_ | 1850087457226227712 |
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| author | Hemant Joshi Sakshi Bhushan Tanisha Dimri Deepak Sharma Katrin Sak Abhishek Chauhan Ritu Chauhan Shafiul Haque Faraz Ahmad Manoj Kumar Hardeep Singh Tuli Damandeep Kaur |
| author_facet | Hemant Joshi Sakshi Bhushan Tanisha Dimri Deepak Sharma Katrin Sak Abhishek Chauhan Ritu Chauhan Shafiul Haque Faraz Ahmad Manoj Kumar Hardeep Singh Tuli Damandeep Kaur |
| author_sort | Hemant Joshi |
| collection | DOAJ |
| description | Abstract Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side effects, especially neurotoxicity, besides its poor water solubility. Therefore, over the recent years, several semisynthetic derivatives of harmine have been prepared and studied concerning their abilities to inhibit tumor cell proliferation, survival, angiogenesis, migration, and invasion in diverse preclinical models. This review article summarizes the anticancer effects of harmine and its synthetic derivatives, demonstrating their high potential to be developed as novel anticancer drugs to supplement our current therapeutic arsenal in the fight against the globally increasing rate of malignant disorders. |
| format | Article |
| id | doaj-art-01ddd9ef444c43c1baa88ab261fda2c7 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-01ddd9ef444c43c1baa88ab261fda2c72025-08-20T02:43:13ZengSpringerDiscover Oncology2730-60112025-02-0116111210.1007/s12672-025-01893-wAnti-tumor potential of Harmine and its derivatives: recent trends and advancementsHemant Joshi0Sakshi Bhushan1Tanisha Dimri2Deepak Sharma3Katrin Sak4Abhishek Chauhan5Ritu Chauhan6Shafiul Haque7Faraz Ahmad8Manoj Kumar9Hardeep Singh Tuli10Damandeep Kaur11School of Biotechnology, Jawaharlal Nehru UniversityDepartment of Plant Science, University of ManitobaDepartment of Biotechnology, All India Institute of Medical ScienceDepartment of Plant Science, University of ManitobaNGO PraeventioAmity Institute of Environmental Toxicology Safety and Management, Amity UniversityDepartment of Biotechnology, Graphic Era Deemed to Be UniversityResearch and Scientific Studies Unit, College of Nursing and Health Sciences, Jazan UniversityDepartment of Biotechnology, School of Bio-Sciences and Technology (SBST), Vellore Institute of TechnologyDepartment of Chemistry, Maharishi Markandeshwar University SadopurDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University)University Center for Research and Development (UCRD), Chandigarh UniversityAbstract Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side effects, especially neurotoxicity, besides its poor water solubility. Therefore, over the recent years, several semisynthetic derivatives of harmine have been prepared and studied concerning their abilities to inhibit tumor cell proliferation, survival, angiogenesis, migration, and invasion in diverse preclinical models. This review article summarizes the anticancer effects of harmine and its synthetic derivatives, demonstrating their high potential to be developed as novel anticancer drugs to supplement our current therapeutic arsenal in the fight against the globally increasing rate of malignant disorders.https://doi.org/10.1007/s12672-025-01893-wHarmineAlkaloidAnti-cancerNatural productCancer therapeutics |
| spellingShingle | Hemant Joshi Sakshi Bhushan Tanisha Dimri Deepak Sharma Katrin Sak Abhishek Chauhan Ritu Chauhan Shafiul Haque Faraz Ahmad Manoj Kumar Hardeep Singh Tuli Damandeep Kaur Anti-tumor potential of Harmine and its derivatives: recent trends and advancements Discover Oncology Harmine Alkaloid Anti-cancer Natural product Cancer therapeutics |
| title | Anti-tumor potential of Harmine and its derivatives: recent trends and advancements |
| title_full | Anti-tumor potential of Harmine and its derivatives: recent trends and advancements |
| title_fullStr | Anti-tumor potential of Harmine and its derivatives: recent trends and advancements |
| title_full_unstemmed | Anti-tumor potential of Harmine and its derivatives: recent trends and advancements |
| title_short | Anti-tumor potential of Harmine and its derivatives: recent trends and advancements |
| title_sort | anti tumor potential of harmine and its derivatives recent trends and advancements |
| topic | Harmine Alkaloid Anti-cancer Natural product Cancer therapeutics |
| url | https://doi.org/10.1007/s12672-025-01893-w |
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