Sputum as a source of adipokines in bronchial asthma
Forty-four patients with allergic (ABA) and non-allergic (NABA) variants of bronchial asthma (BA) were examined to evaluate levels of key adipokines (leptin, resistin, adiponectin) in sputum in different variants of BA. Adipokines in sputum and blood plasma were measured by Enzyme-Linked Immunosorbe...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2014-09-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/56 |
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| author | V. N. Mineev T. M. Lalaeva T. S. Vasiljeva A. A. Kuzmina |
| author_facet | V. N. Mineev T. M. Lalaeva T. S. Vasiljeva A. A. Kuzmina |
| author_sort | V. N. Mineev |
| collection | DOAJ |
| description | Forty-four patients with allergic (ABA) and non-allergic (NABA) variants of bronchial asthma (BA) were examined to evaluate levels of key adipokines (leptin, resistin, adiponectin) in sputum in different variants of BA. Adipokines in sputum and blood plasma were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The indices that reflect the percentage of adipokines in sputum regarding adipokines in plasma of the same patients were worked out to evaluate the ratio of levels of corresponding adipokines in plasma and sputum in patients with BA. Two regularities are clearly seen in the study: the first - levels of proinflammatory adipokines (leptin, resistin) in sputum in ABA correlate directly with indicators of respiratory function but levels of anti-inflammatory adipokines (adiponectin) in sputum correlate inversely with indicators of respiratory function; the second -correlation of levels of the studied adipokines with indicators of respiratory function are almost not revealed in NABA. The first regularity reflects the important fact that the content of adipokines in bronchial secretion is to a certain extent one of regulating local mechanisms in target organ controlled system levels of corresponding adipokines in exacerbation of BA. |
| format | Article |
| id | doaj-art-01d2955c8f8846c5a32bc23963bcf102 |
| institution | Kabale University |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-01d2955c8f8846c5a32bc23963bcf1022025-08-20T03:59:57ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072014-09-01213344010.24884/1607-4181-2014-21-3-34-4052Sputum as a source of adipokines in bronchial asthmaV. N. Mineev0T. M. Lalaeva1T. S. Vasiljeva2A. A. Kuzmina3Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаForty-four patients with allergic (ABA) and non-allergic (NABA) variants of bronchial asthma (BA) were examined to evaluate levels of key adipokines (leptin, resistin, adiponectin) in sputum in different variants of BA. Adipokines in sputum and blood plasma were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The indices that reflect the percentage of adipokines in sputum regarding adipokines in plasma of the same patients were worked out to evaluate the ratio of levels of corresponding adipokines in plasma and sputum in patients with BA. Two regularities are clearly seen in the study: the first - levels of proinflammatory adipokines (leptin, resistin) in sputum in ABA correlate directly with indicators of respiratory function but levels of anti-inflammatory adipokines (adiponectin) in sputum correlate inversely with indicators of respiratory function; the second -correlation of levels of the studied adipokines with indicators of respiratory function are almost not revealed in NABA. The first regularity reflects the important fact that the content of adipokines in bronchial secretion is to a certain extent one of regulating local mechanisms in target organ controlled system levels of corresponding adipokines in exacerbation of BA.https://www.sci-notes.ru/jour/article/view/56лептинрезистинадипонектинмокротабронхиальная астмаleptinresistinadiponectinsputumbronchial asthma |
| spellingShingle | V. N. Mineev T. M. Lalaeva T. S. Vasiljeva A. A. Kuzmina Sputum as a source of adipokines in bronchial asthma Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова лептин резистин адипонектин мокрота бронхиальная астма leptin resistin adiponectin sputum bronchial asthma |
| title | Sputum as a source of adipokines in bronchial asthma |
| title_full | Sputum as a source of adipokines in bronchial asthma |
| title_fullStr | Sputum as a source of adipokines in bronchial asthma |
| title_full_unstemmed | Sputum as a source of adipokines in bronchial asthma |
| title_short | Sputum as a source of adipokines in bronchial asthma |
| title_sort | sputum as a source of adipokines in bronchial asthma |
| topic | лептин резистин адипонектин мокрота бронхиальная астма leptin resistin adiponectin sputum bronchial asthma |
| url | https://www.sci-notes.ru/jour/article/view/56 |
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