Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature
The management of glioblastoma multiforme (GBM) is in most cases complex and must be specifically tailored to the needs of the patient with the goals of extended survival and improved quality of life. Despite advancements in therapy, treatment outcomes remain almost universally poor. Salvage treatm...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/431857 |
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| author | Erik W. Larson Halloran E. Peterson Robert K. Fairbanks Wayne T. Lamoreaux Alexander R. Mackay Jason A. Call John J. Demakas Barton S. Cooke Christopher M. Lee |
| author_facet | Erik W. Larson Halloran E. Peterson Robert K. Fairbanks Wayne T. Lamoreaux Alexander R. Mackay Jason A. Call John J. Demakas Barton S. Cooke Christopher M. Lee |
| author_sort | Erik W. Larson |
| collection | DOAJ |
| description | The management of glioblastoma multiforme (GBM) is in most cases complex and must be specifically tailored to the needs of the patient with the goals of extended survival and improved quality of life. Despite advancements in therapy, treatment outcomes remain almost universally poor. Salvage treatment options for the recurrence of the disease is an area of intense study. The following case highlights the utility of Gamma Knife Radiosurgery (GKRS) as a salvage treatment. In this clinical situation, three sequential GKRS treatments led to prolonged survival (beyond four years after diagnosis) and improved quality of life in a patient who was unable to receive further chemotherapy regimens and was unwilling to undergo further aggressive resection. To date, there have been few reports of three or more sequential GKRS treatment sessions utilized as salvage therapy for recurrent GBM in patients who can no longer tolerate chemotherapy. This report provides evidence that aggressive local treatment with GKRS at the time of recurrence may be appropriate, depending on a patient’s individual clinical situation, and can lead to prolonged survival and improved quality of life. |
| format | Article |
| id | doaj-art-01d1411a77614c63b1ca512c82407e94 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-01d1411a77614c63b1ca512c82407e942025-02-03T01:11:50ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/431857431857Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the LiteratureErik W. Larson0Halloran E. Peterson1Robert K. Fairbanks2Wayne T. Lamoreaux3Alexander R. Mackay4Jason A. Call5John J. Demakas6Barton S. Cooke7Christopher M. Lee8Gamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USACancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAGamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USAThe management of glioblastoma multiforme (GBM) is in most cases complex and must be specifically tailored to the needs of the patient with the goals of extended survival and improved quality of life. Despite advancements in therapy, treatment outcomes remain almost universally poor. Salvage treatment options for the recurrence of the disease is an area of intense study. The following case highlights the utility of Gamma Knife Radiosurgery (GKRS) as a salvage treatment. In this clinical situation, three sequential GKRS treatments led to prolonged survival (beyond four years after diagnosis) and improved quality of life in a patient who was unable to receive further chemotherapy regimens and was unwilling to undergo further aggressive resection. To date, there have been few reports of three or more sequential GKRS treatment sessions utilized as salvage therapy for recurrent GBM in patients who can no longer tolerate chemotherapy. This report provides evidence that aggressive local treatment with GKRS at the time of recurrence may be appropriate, depending on a patient’s individual clinical situation, and can lead to prolonged survival and improved quality of life.http://dx.doi.org/10.1155/2013/431857 |
| spellingShingle | Erik W. Larson Halloran E. Peterson Robert K. Fairbanks Wayne T. Lamoreaux Alexander R. Mackay Jason A. Call John J. Demakas Barton S. Cooke Christopher M. Lee Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature |
| title_full | Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature |
| title_fullStr | Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature |
| title_full_unstemmed | Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature |
| title_short | Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature |
| title_sort | long term survival and improved quality of life following multiple repeat gamma knife radiosurgeries for recurrent glioblastoma multiforme a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/431857 |
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