Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients
Purpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macul...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/7043752 |
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| author | Christoph Nützi Andreas Schötzau Matthias C. Grieshaber |
| author_facet | Christoph Nützi Andreas Schötzau Matthias C. Grieshaber |
| author_sort | Christoph Nützi |
| collection | DOAJ |
| description | Purpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). Results. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45). Conclusion. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG. |
| format | Article |
| id | doaj-art-01cf35f8eb9a48d697fddfd94af03765 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-01cf35f8eb9a48d697fddfd94af037652025-02-03T06:11:30ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/70437527043752Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma PatientsChristoph Nützi0Andreas Schötzau1Matthias C. Grieshaber2Department of Ophthalmology, Glaucoma Service, University of Basel, Basel, SwitzerlandDepartment of Ophthalmology, Glaucoma Service, University of Basel, Basel, SwitzerlandDepartment of Ophthalmology, Glaucoma Service, University of Basel, Basel, SwitzerlandPurpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). Results. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45). Conclusion. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.http://dx.doi.org/10.1155/2017/7043752 |
| spellingShingle | Christoph Nützi Andreas Schötzau Matthias C. Grieshaber Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients Journal of Ophthalmology |
| title | Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients |
| title_full | Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients |
| title_fullStr | Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients |
| title_full_unstemmed | Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients |
| title_short | Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients |
| title_sort | structure and function relationship of activated retinal glia in primary open angle glaucoma patients |
| url | http://dx.doi.org/10.1155/2017/7043752 |
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