Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/181324 |
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| _version_ | 1832553653168242688 |
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| author | Montserrat Estruch José Luis Sánchez-Quesada Jordi Ordóñez Llanos Sònia Benítez |
| author_facet | Montserrat Estruch José Luis Sánchez-Quesada Jordi Ordóñez Llanos Sònia Benítez |
| author_sort | Montserrat Estruch |
| collection | DOAJ |
| description | Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect. |
| format | Article |
| id | doaj-art-01c628be4ebf41a88a681d99ae575380 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01c628be4ebf41a88a681d99ae5753802025-02-03T05:53:33ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/181324181324Electronegative LDL: A Circulating Modified LDL with a Role in InflammationMontserrat Estruch0José Luis Sánchez-Quesada1Jordi Ordóñez Llanos2Sònia Benítez3Servei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainServei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainDepartament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Barcelona, SpainServei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainElectronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect.http://dx.doi.org/10.1155/2013/181324 |
| spellingShingle | Montserrat Estruch José Luis Sánchez-Quesada Jordi Ordóñez Llanos Sònia Benítez Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation Mediators of Inflammation |
| title | Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation |
| title_full | Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation |
| title_fullStr | Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation |
| title_full_unstemmed | Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation |
| title_short | Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation |
| title_sort | electronegative ldl a circulating modified ldl with a role in inflammation |
| url | http://dx.doi.org/10.1155/2013/181324 |
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