The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation
Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissol...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2018/5908167 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556654362624000 |
|---|---|
| author | David W. Pittman Alexandra M. Brantly Alexandra L. Drobonick Hannah T. King Daniel C. Mesta Caroline G. Richards Manjari Lal Manshun Lai |
| author_facet | David W. Pittman Alexandra M. Brantly Alexandra L. Drobonick Hannah T. King Daniel C. Mesta Caroline G. Richards Manjari Lal Manshun Lai |
| author_sort | David W. Pittman |
| collection | DOAJ |
| description | Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT−) and FDTs containing LPV/r (FDT+). Rats showed no change in consumption patterns for the placebo FDT− compared with control solutions. Rats can detect but do not avoid FDT+ at body-weight-adjusted dosages in both brief-access (30-s) and long-term (23 h) consumption tests. There is an aversive response to concentrated doses of FDT+ during brief-access tests that cannot be masked by 25% sucrose. However, the strongest FDT+ concentration was not rejected when mixed with 50 g of applesauce, banana sauce, or rice cereal baby foodstuffs. The averseness of the FDT+ was associated with the presence of LPV/r and not the FDT− formulation itself. The novel FDT formulation appears to be a palatable delivery mechanism for oral antiretroviral pharmaceuticals especially when mixed with baby foodstuffs. |
| format | Article |
| id | doaj-art-01c40107320847698712c26ce9599823 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-01c40107320847698712c26ce95998232025-02-03T05:44:39ZengWileyAIDS Research and Treatment2090-12402090-12592018-01-01201810.1155/2018/59081675908167The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet FormulationDavid W. Pittman0Alexandra M. Brantly1Alexandra L. Drobonick2Hannah T. King3Daniel C. Mesta4Caroline G. Richards5Manjari Lal6Manshun Lai7Department of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USADepartment of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USADepartment of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USADepartment of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USADepartment of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USADepartment of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USAPATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USAPATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USANegative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT−) and FDTs containing LPV/r (FDT+). Rats showed no change in consumption patterns for the placebo FDT− compared with control solutions. Rats can detect but do not avoid FDT+ at body-weight-adjusted dosages in both brief-access (30-s) and long-term (23 h) consumption tests. There is an aversive response to concentrated doses of FDT+ during brief-access tests that cannot be masked by 25% sucrose. However, the strongest FDT+ concentration was not rejected when mixed with 50 g of applesauce, banana sauce, or rice cereal baby foodstuffs. The averseness of the FDT+ was associated with the presence of LPV/r and not the FDT− formulation itself. The novel FDT formulation appears to be a palatable delivery mechanism for oral antiretroviral pharmaceuticals especially when mixed with baby foodstuffs.http://dx.doi.org/10.1155/2018/5908167 |
| spellingShingle | David W. Pittman Alexandra M. Brantly Alexandra L. Drobonick Hannah T. King Daniel C. Mesta Caroline G. Richards Manjari Lal Manshun Lai The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation AIDS Research and Treatment |
| title | The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation |
| title_full | The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation |
| title_fullStr | The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation |
| title_full_unstemmed | The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation |
| title_short | The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation |
| title_sort | palatability of lopinavir and ritonavir delivered by an innovative freeze dried fast dissolving tablet formulation |
| url | http://dx.doi.org/10.1155/2018/5908167 |
| work_keys_str_mv | AT davidwpittman thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT alexandrambrantly thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT alexandraldrobonick thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT hannahtking thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT danielcmesta thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT carolinegrichards thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT manjarilal thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT manshunlai thepalatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT davidwpittman palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT alexandrambrantly palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT alexandraldrobonick palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT hannahtking palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT danielcmesta palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT carolinegrichards palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT manjarilal palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation AT manshunlai palatabilityoflopinavirandritonavirdeliveredbyaninnovativefreezedriedfastdissolvingtabletformulation |