Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study

Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study

Background We hypothesized treatment with nivolumab and stereotactic radiosurgery (SRS) would be feasible, well tolerated, and may improve intracranial tumor control over SRS alone for breast cancer brain metastases (BCBM).Methods The study is a phase Ib trial of nivolumab and SRS for BCBM. Clinical...

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Main Authors: Brian J Czerniecki, Sungjune Kim, Loretta S Loftus, Roberto Díaz, Hatem Soliman, Ricardo L B Costa, Hyo S Han, Younchul Kim, Peter A Forsyth, Kamran A Ahmed, Min Hsuan Wang, Michelle DeJesus, John A Arrington, Aixa E Soyano, Avan J Armaghani, Marilin Rosa, Jimmy J Caudell, Arnold B Etame, Nam D Tran, Hsiang-Hsuan Michael Yu
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e011432.full
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