Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis
Abstract This study aims to investigate the relationship between Parkinson's disease (PD) and colorectal cancer (CRC) risk by a systematic review and meta‐analysis. Using Embase, Pubmed, and Cochrane Library databases, 21 articles reporting clinical data of 1,635,873 PD patients and 10,388,842...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-06-01
|
| Series: | Ibrain |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ibra.12193 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850113910634446848 |
|---|---|
| author | Meng‐Dan Su Tian‐Hong Wang Hao‐Wen Zhang Ke‐Yu Cao Fei Liu |
| author_facet | Meng‐Dan Su Tian‐Hong Wang Hao‐Wen Zhang Ke‐Yu Cao Fei Liu |
| author_sort | Meng‐Dan Su |
| collection | DOAJ |
| description | Abstract This study aims to investigate the relationship between Parkinson's disease (PD) and colorectal cancer (CRC) risk by a systematic review and meta‐analysis. Using Embase, Pubmed, and Cochrane Library databases, 21 articles reporting clinical data of 1,635,873 PD patients and 10,388,842 healthy individuals were finally included. Based on the results of pooled analysis, we found that PD patients exhibited a decreased risk of CRC (relative risk (RR) = 0.74; 95% confidence interval (CI), 0.68–0.80). In contrast to case‐control (RR = 0.80; 95% CI, 0.64–1) and cohort studies (RR = 0.72; 95% CI, 0.66–0.79), the combined risk of PD patients with CRC in Asian nations (RR = 0.67; 95% CI, 0.58–0.78) was lower than that in Western countries (RR = 0.76; 95% CI, 0.70–0.82). In comparison to rectal cancer (RR = 0.82; 95% CI, 0.69–0.97), PD patients exhibited a lower combined risk of colon cancer (RR = 0.76; 95% CI, 0.67–0.86). Furthermore, the combined CRC risks for patients in studies published before 2010 and after 2010 were 0.76 (RR = 0.76; 95% CI, 0.66–0.88) and 0.74 (RR = 0.74; 95% CI, 0.68–0.80), respectively. These findings indicate that patients with PD had a reduced risk of CRC. Future studies are merited in exploring pathological molecular linkages or underlying mechanisms of inverse association between CRC and PD. |
| format | Article |
| id | doaj-art-01be7c93bc284e4b95859d751e1d7407 |
| institution | OA Journals |
| issn | 2313-1934 2769-2795 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj-art-01be7c93bc284e4b95859d751e1d74072025-08-20T02:37:02ZengWiley-VCHIbrain2313-19342769-27952025-06-0111220521410.1002/ibra.12193Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysisMeng‐Dan Su0Tian‐Hong Wang1Hao‐Wen Zhang2Ke‐Yu Cao3Fei Liu4Department of Anesthesiology West China Hospital, Sichuan University Chengdu ChinaDepartment of Anesthesiology West China Hospital, Sichuan University Chengdu ChinaDepartment of Thoracic Surgery West China Hospital, Sichuan University Chengdu ChinaDepartment of Nursing West China Hospital, Sichuan University/West China School of Nursing, Sichuan University Chengdu ChinaDepartment of Anesthesiology West China Hospital, Sichuan University Chengdu ChinaAbstract This study aims to investigate the relationship between Parkinson's disease (PD) and colorectal cancer (CRC) risk by a systematic review and meta‐analysis. Using Embase, Pubmed, and Cochrane Library databases, 21 articles reporting clinical data of 1,635,873 PD patients and 10,388,842 healthy individuals were finally included. Based on the results of pooled analysis, we found that PD patients exhibited a decreased risk of CRC (relative risk (RR) = 0.74; 95% confidence interval (CI), 0.68–0.80). In contrast to case‐control (RR = 0.80; 95% CI, 0.64–1) and cohort studies (RR = 0.72; 95% CI, 0.66–0.79), the combined risk of PD patients with CRC in Asian nations (RR = 0.67; 95% CI, 0.58–0.78) was lower than that in Western countries (RR = 0.76; 95% CI, 0.70–0.82). In comparison to rectal cancer (RR = 0.82; 95% CI, 0.69–0.97), PD patients exhibited a lower combined risk of colon cancer (RR = 0.76; 95% CI, 0.67–0.86). Furthermore, the combined CRC risks for patients in studies published before 2010 and after 2010 were 0.76 (RR = 0.76; 95% CI, 0.66–0.88) and 0.74 (RR = 0.74; 95% CI, 0.68–0.80), respectively. These findings indicate that patients with PD had a reduced risk of CRC. Future studies are merited in exploring pathological molecular linkages or underlying mechanisms of inverse association between CRC and PD.https://doi.org/10.1002/ibra.12193colorectal cancermeta‐analysisParkinson's diseasepooled analysissystematic review |
| spellingShingle | Meng‐Dan Su Tian‐Hong Wang Hao‐Wen Zhang Ke‐Yu Cao Fei Liu Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis Ibrain colorectal cancer meta‐analysis Parkinson's disease pooled analysis systematic review |
| title | Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis |
| title_full | Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis |
| title_fullStr | Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis |
| title_full_unstemmed | Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis |
| title_short | Association between Parkinson's disease and risk of colorectal cancer: A systematic review and meta‐analysis |
| title_sort | association between parkinson s disease and risk of colorectal cancer a systematic review and meta analysis |
| topic | colorectal cancer meta‐analysis Parkinson's disease pooled analysis systematic review |
| url | https://doi.org/10.1002/ibra.12193 |
| work_keys_str_mv | AT mengdansu associationbetweenparkinsonsdiseaseandriskofcolorectalcancerasystematicreviewandmetaanalysis AT tianhongwang associationbetweenparkinsonsdiseaseandriskofcolorectalcancerasystematicreviewandmetaanalysis AT haowenzhang associationbetweenparkinsonsdiseaseandriskofcolorectalcancerasystematicreviewandmetaanalysis AT keyucao associationbetweenparkinsonsdiseaseandriskofcolorectalcancerasystematicreviewandmetaanalysis AT feiliu associationbetweenparkinsonsdiseaseandriskofcolorectalcancerasystematicreviewandmetaanalysis |