125I inhibits the progression of cervical cancer by upregulating the HSF1/PU.1/SYK signaling pathway and consequently enhancing the apoptotic response mediated by ROS/USP7/P53

125I inhibits the progression of cervical cancer by upregulating the HSF1/PU.1/SYK signaling pathway and consequently enhancing the apoptotic response mediated by ROS/USP7/P53

Abstract 125I (iodine-125) is a radioactive isotope commonly used in the treatment of cervical cancer, especially in brachytherapy. This study investigates the molecular mechanism by which 125I radiotherapy inhibits the progression of cervical cancer. C33A cervical cancer cells were subjected to irr...

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Bibliographic Details
Main Authors: Xiaomei Fan, Xiaoliang Liang, Yunfeng Guo, Ge Jin, Dong Ming, Xingwei An
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cervical cancer
125I
HSF1/PU.1/SYK signaling pathway
ROS/USP7/P53 signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-99214-2
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https://doi.org/10.1038/s41598-025-99214-2

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