Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report
Verrucous carcinoma, a well-differentiated variant of squamous cell carcinoma with low-grade malignancy, is often associated with localized human papillomavirus (HPV) infection and excessive penile foreskin. We report a 45-year-old male who presented with a verrucous plaque on the glans penis for ov...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004745 |
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| author | Runqun Liu Xiaoqing Xiang Yanliang Li Guozhang Ma Junhong Ye |
| author_facet | Runqun Liu Xiaoqing Xiang Yanliang Li Guozhang Ma Junhong Ye |
| author_sort | Runqun Liu |
| collection | DOAJ |
| description | Verrucous carcinoma, a well-differentiated variant of squamous cell carcinoma with low-grade malignancy, is often associated with localized human papillomavirus (HPV) infection and excessive penile foreskin. We report a 45-year-old male who presented with a verrucous plaque on the glans penis for over four months, along with itching. Examination revealed a verrucous, erosive lesion with a cauliflower-like surface, firm texture, and irregular shape, accompanied by pain, bleeding, and a foul odor. Syphilis and HIV tests were negative, and a biopsy confirmed verrucous carcinoma.The patient underwent initial circumcision at a local hospital, but persistent lesions raised concerns about further surgery impairing sexual function and anatomical integrity. To preserve both anatomical and functional integrity, the patient opted for Hematoporphyrin Derivative-Photodynamic Therapy (HpD-PDT). Post-treatment, the lesions regressed, and after four years of follow-up, there was no scarring or recurrence. The clinical outcome was favorable with complete lesion regression.We propose that PDT is a viable treatment option for penile verrucous carcinoma, offering advantages over traditional methods in terms of function preservation and cosmetic outcomes. |
| format | Article |
| id | doaj-art-01abcc6de3d94eef890f9c6e6d26662f |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-01abcc6de3d94eef890f9c6e6d26662f2025-02-01T04:11:42ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104438Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case reportRunqun Liu0Xiaoqing Xiang1Yanliang Li2Guozhang Ma3Junhong Ye4Heilongjiang University of Chinese Medicine,Harbin City, Heilongjiang Province, ChinaHeilongjiang University of Chinese Medicine,Harbin City, Heilongjiang Province, ChinaBeijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen City, ChinaHeilongjiang Provincial Hospital, dermatology department, Harbin City, Heilongjiang Province, ChinaThe Fifth People's Hospital of Hainan Province,Haikou City, Hainan Province, China; Corresponding author.Verrucous carcinoma, a well-differentiated variant of squamous cell carcinoma with low-grade malignancy, is often associated with localized human papillomavirus (HPV) infection and excessive penile foreskin. We report a 45-year-old male who presented with a verrucous plaque on the glans penis for over four months, along with itching. Examination revealed a verrucous, erosive lesion with a cauliflower-like surface, firm texture, and irregular shape, accompanied by pain, bleeding, and a foul odor. Syphilis and HIV tests were negative, and a biopsy confirmed verrucous carcinoma.The patient underwent initial circumcision at a local hospital, but persistent lesions raised concerns about further surgery impairing sexual function and anatomical integrity. To preserve both anatomical and functional integrity, the patient opted for Hematoporphyrin Derivative-Photodynamic Therapy (HpD-PDT). Post-treatment, the lesions regressed, and after four years of follow-up, there was no scarring or recurrence. The clinical outcome was favorable with complete lesion regression.We propose that PDT is a viable treatment option for penile verrucous carcinoma, offering advantages over traditional methods in terms of function preservation and cosmetic outcomes.http://www.sciencedirect.com/science/article/pii/S1572100024004745Verrucous carcinomaHematoporphyrin injectionPhotodynamic therapy |
| spellingShingle | Runqun Liu Xiaoqing Xiang Yanliang Li Guozhang Ma Junhong Ye Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report Photodiagnosis and Photodynamic Therapy Verrucous carcinoma Hematoporphyrin injection Photodynamic therapy |
| title | Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report |
| title_full | Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report |
| title_fullStr | Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report |
| title_full_unstemmed | Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report |
| title_short | Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report |
| title_sort | photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma a case report |
| topic | Verrucous carcinoma Hematoporphyrin injection Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004745 |
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